Pyruvate Dehydrogenase Complex

Question 1

PDC and the krebs cycle takes place in what part of the cell?

Answer 1

the matrix of the mitochondria

Question 2

what transport protein takes pyruvate from the cytosol to the mito matrix?

Answer 2

pyruvate translocase

Question 3

dehydrogenase in these terms means to

Answer 3

oxidized the pyruvate molecule (dehydrating/oxidative carboxylation)

Question 4

the cofactor involved in this reaction is

Answer 4

coenzyme A

Question 5

while pyruvate is being oxidized, what is being reduced?

Answer 5

NAD+ is reduced to NADH

Question 6

during the oxidation of pyruvate a carbon molecule is lost thus what is produced?

Answer 6

carbon dioxide (CO2)

Question 7

the pyruvate oxidation to acetyl CoA has a delta G of what and the reaction is

Answer 7

negative delta G and the reaction is irreversible

Question 8

what are the two pathways of acetyl CoA once it is produced from the oxidization of pyruvate?

Answer 8

1) enters into the Krebs cycle for further production of ATP, NADH, and FADH2
2) used for fatty acid production when ATP levels are high thus not necessary to enter into Krebs cycle

Question 9

what is the major regulator of which pathway acetyl CoA will take?

Answer 9

allosteric regulation

Question 10

allosteric activators in this complex are

Answer 10

the reactants: CoA, NAD+, pyruvate

AMP and calcium

Question 11

allosteric inhibitors in this complex are

Answer 11

products: acetyl CoA, NADH

ATP, fatty acids

Question 12

molecular structure of acetyl CoA

Answer 12

C-C-S-CoA