Purine and pyrimidine metabolism Flashcards
purine metabolism- purine synthesis begins with ____________ and gets converted to _____ using ______.
Ribose-5-phosphate (from PPP), PRPP, PRPP synthetase
purine metabolism: PRPP is then converted to IMP with the help of some __.
AA
IMP is then converted to ____ and GMP (IMP is the first purine made here)
AMP
AMP and GMP are then converted to ____ and ___ by ribonucleotide reductase
dAMP and dGMP
converting AMP and GMP to dAMP and dGMP by ribonucleotide reductase is inhibited by ____.
hydroxyurea (anti-cancer drug)
salvage pathways of purine synthesis is also available (three)
- hypoxanthine
- guanine
- adenine
hypoxanthine-IMP
done by hypoxanthine-guanine phosphoribosyltransferase
guanine-GMP
done by hypoxanthine-guanine phosphoribosyltransferase
adenine-AMP
done by adenine phosphoribosyltransferase
purine degration: ___, _____, and IMP all get converted to Uric acid
AMP, GMP, and IMP
when there is an abundance of uric acid, it will lead to ____.
Gout
for purine degradation, This is treated by using allopurinol which will inhibit the enzyme responsible for creating uric acid which is ______________.
xanthine oxidase
pyrimidine metabolism: pyrimidine synthesis begins with the _______.
AA glutamine
in Pyrimidine metabolism, glutamine is converted to ______ which can in turn get converted to _____ and _____.
UMP, CMP, and TMP
in pyrimidine synthesis, dUMP is converted to dTMP by ______.
thymidylate synthase
