PUO

Question 1

What are the four classes of DDx with a patient of PUO

Answer 1

Malignancy, infection, CT disorders and other

Question 2

What typical malignancies give fever

Answer 2

Lymphomas, leukemias, mets, liver cancer etc

Question 3

What are some typical CT disorders

Answer 3

SLE, Temporal arteritis, polymyalgia rheumatica, granulomatous diseases and acute thyroiditis

Question 4

WHat are some common infections

Answer 4

SBE, TB, HIV and atypical pneumonia

Question 5

Where does the PGE2 act on in the hypothalamus

Answer 5

The pre-optic area of the anterior hypothalamus

Question 6

How is heat lost

Answer 6

peripheral vasodilation, sweating and reduced physical activity

Question 7

How is heat maintained and conserved

Answer 7

peripheral vasoconstriction, piloerection and warmth seeking behaviour

Question 8

How is heat produced

Answer 8

release of thyroid hormone, glucocorticoids and catecholamines

Question 9

WHat is the definition of PUO

Answer 9

2-3 weeks of a temperature above 38.3 and there is no diagnosis after intelligent investigations

Question 10

What is the diurnal variation in temperature

Answer 10

Slightly colder in and morning and hotter in the afternoon