Pulmonary Flashcards
Albuterol (ProAir, Ventolin)
Inhaled beta agonist (-terol)
Inhaled beta agonist MOA
Antagonise B2 receptors = Bronchodialation
Inhaled beta agonist AE
Tachycardia, Tremor, HypoKalemia
Inhaled beta agonist Other
“Short acting are SABA
Long Acting are LABA”
Tiotropium (Spiriva)
Inhaled Antimuscarinic (AKA: anticholinergic)
Inhaled Antimuscarinic MOA
Bind to M3 in airway smooth muscle; antagnizes ACh = bronchodilation
Inhaled Antimuscarinic AE
DRY MOUTH
Inhaled Antimuscarinic other
“short acting are SAMA
Long Acting are LAMA”
Fluticasone (Flovent)
Inhaled Corticosteriods (ICS)
ICS Indication
Used for exacerbation or more severe disease
ICS MOA
really strong anti-inflammatory
ICS AE
oral candidiasis, hoarse voice, skin bruisign, increaed risk pneumonia in some pop; elderly on high doses: osteoporosis, cataracts
ICS Other
no evidence of benefit in stable COPD
Fluticasone/salmeterol (ICS/LABA; Advair)
Combination Inhaled Meds
formoterol/budesonide (LABA/ICS; Symbicort
Combination Inhaled Meds
albuterol/ipratropium (SABA/SAMA; Combivent)
Combination Inhaled Meds
Combination Inhaled Meds MOA
increased Bronchodilation
Combination Inhaled Meds
Other
short acting with short, long acting with long
Combination Inhaled Meds Indication
Combine increased bronchodilation lower AEs
Hypertonic saline
Inhaled mucolytic
dornase alfa (Pulmozyme)
Inhaled mucolytic
Inhaled mucolytic MOA
split DISULFIDE bonds
Drugs which decrease the viscosity of respiratory secretions (mucus)
Pulmonary drugs PT
“TRYING TO DECREASE SYMPTOMS AND INCREASE EXERCISE TOLERANCE TO IMROVE HEALTH STATUS (COPD)
ANTIBIOTIC CAN BE USED IN ACUTE EXACERBATION”
Montelukast (Singulair)
Lukotriene
This one is primarly used for asthma
Omalizumab (Xolair)
Immunomodulator: Anti IgE
Orkambi
CFTR modulaters
Symdeco
CFTR modulaters
Lukotriene MOA
“Antagonises the leukotriene receptor (competitive)
esoinophils”
Lukotriene AE
very well tolerated
Lukotriene Other
Leukotriene receptor antagonist (LTRA)
Immunomodulator: Anti IgE MOA
Binds IgE antibody»_space; on mast cells and basophils»_space; limits activation and release of allergic response mediators
Immunomodulator: Anti IgE AE
injection site reaction, very rere but anaphylactic
CFTR modulaters MOA
“Ivacaftor: improves CFTR activity = chloride channels open longer to improve chloride transport
Tezacaftor and lumacaftor: facilitate trafficking of CFTR to the cell membrane surface = improved chloride transport INCREASES THE NUMBER ON THE SURFACE OF THE CELL
“
CFTR modulaters AE
“headache, GI, respritory
if baseline FEV <40% then could become morre serious, dizziness, hypertension”
