Pulmonary

Question 1

Albuterol (ProAir, Ventolin)

Answer 1

Inhaled beta agonist (-terol)

Question 2

Inhaled beta agonist MOA

Answer 2

Antagonise B2 receptors = Bronchodialation

Question 3

Inhaled beta agonist AE

Answer 3

Tachycardia, Tremor, HypoKalemia

Question 4

Inhaled beta agonist Other

Answer 4

“Short acting are SABA

Long Acting are LABA”

Question 5

Tiotropium (Spiriva)

Answer 5

Inhaled Antimuscarinic (AKA: anticholinergic)

Question 6

Inhaled Antimuscarinic MOA

Answer 6

Bind to M3 in airway smooth muscle; antagnizes ACh = bronchodilation

Question 7

Inhaled Antimuscarinic AE

Answer 7

DRY MOUTH

Question 8

Inhaled Antimuscarinic other

Answer 8

“short acting are SAMA

Long Acting are LAMA”

Question 9

Fluticasone (Flovent)

Answer 9

Inhaled Corticosteriods (ICS)

Question 10

ICS Indication

Answer 10

Used for exacerbation or more severe disease

Question 11

ICS MOA

Answer 11

really strong anti-inflammatory

Question 12

ICS AE

Answer 12

oral candidiasis, hoarse voice, skin bruisign, increaed risk pneumonia in some pop; elderly on high doses: osteoporosis, cataracts

Question 13

ICS Other

Answer 13

no evidence of benefit in stable COPD

Question 14

Fluticasone/salmeterol (ICS/LABA; Advair)

Answer 14

Combination Inhaled Meds

Question 15

formoterol/budesonide (LABA/ICS; Symbicort

Answer 15

Combination Inhaled Meds

Question 16

albuterol/ipratropium (SABA/SAMA; Combivent)

Answer 16

Combination Inhaled Meds

Question 17

Combination Inhaled Meds MOA

Answer 17

increased Bronchodilation

Question 18

Combination Inhaled Meds

Other

Answer 18

short acting with short, long acting with long

Question 19

Combination Inhaled Meds Indication

Answer 19

Combine increased bronchodilation lower AEs

Question 20

Hypertonic saline

Answer 20

Inhaled mucolytic

Question 21

dornase alfa (Pulmozyme)

Answer 21

Inhaled mucolytic

Question 22

Inhaled mucolytic MOA

Answer 22

split DISULFIDE bonds

Drugs which decrease the viscosity of respiratory secretions (mucus)

Question 23

Pulmonary drugs PT

Answer 23

“TRYING TO DECREASE SYMPTOMS AND INCREASE EXERCISE TOLERANCE TO IMROVE HEALTH STATUS (COPD)

ANTIBIOTIC CAN BE USED IN ACUTE EXACERBATION”

Question 24

Montelukast (Singulair)

Answer 24

Lukotriene

This one is primarly used for asthma

Question 25

Omalizumab (Xolair)

Answer 25

Immunomodulator: Anti IgE

Question 26

Orkambi

Answer 26

CFTR modulaters

Question 27

Symdeco

Answer 27

CFTR modulaters

Question 28

Lukotriene MOA

Answer 28

“Antagonises the leukotriene receptor (competitive)

esoinophils”

Question 29

Lukotriene AE

Answer 29

very well tolerated

Question 30

Lukotriene Other

Answer 30

Leukotriene receptor antagonist (LTRA)

Question 31

Immunomodulator: Anti IgE MOA

Answer 31

Binds IgE antibody&raquo_space; on mast cells and basophils&raquo_space; limits activation and release of allergic response mediators

Question 32

Immunomodulator: Anti IgE AE

Answer 32

injection site reaction, very rere but anaphylactic

Question 33

CFTR modulaters MOA

Answer 33

“Ivacaftor: improves CFTR activity = chloride channels open longer to improve chloride transport

Tezacaftor and lumacaftor: facilitate trafficking of CFTR to the cell membrane surface = improved chloride transport INCREASES THE NUMBER ON THE SURFACE OF THE CELL
“

Question 34

CFTR modulaters AE

Answer 34

“headache, GI, respritory

if baseline FEV <40% then could become morre serious, dizziness, hypertension”