pulm vasodilators and mucolytics

Question 1

nitric oxide (Vianox)
Inhaled
via vent, NC, or mask

Answer 1

pulmonary vasodilator (arterial/ vascular smooth muscle)
decrease pulmonary vascular resistance
suppresses endogenous production if therapy is suddenly sopped
inhibits platelet aggregation
may worsen inflammatory response.
half life is 0.1-5 secs

Question 2

epoprostenol (caripul)

Answer 2

pulm. Vasodilator
inhibits platelet aggregation

low flow SVN in ventilator circuit, IV infusion. Run SVN at 3 lpm
(PH is very basic must never be instilled into patient)

Question 3

Alprostadil

Answer 3

vasodilator
maintains patent ductus arteriosum (mostly neonate population)
inhibits platelet aggregation

given via central IV

Question 4

Sildenafil Viagra

Answer 4

pulmonary Vasodilator
may decrease BP
given orally or IV
Also used for Tx of erectile dysfunction

Question 5

L-Epinephrine

Answer 5

sympathomimetic catecholamine– stimulates all sympathetic receptors

Causes upper A/W vasoconstriction= decreases edema, stridor or airway obstruction
cardiac stimulation

given via SVN or instilled
1mg/ml, use 5=10 ml prn

Question 6

Acetylcysteine (mucomyst)

Answer 6

Mucolytic
breaks disulfide bonds holding mucous together
** thins out mucous

SVN or instillation
also used to treat acetaminophen overdose