cholinergic

Question 1

cholinergic agonist direct acting

Answer 1

mimic Ach at the receptor site

binds onto muscarinic and nicotinic receptors stimulating and causing a parasympathetic effect

Question 2

indirect acting

Answer 2

ach will continue to stimulate until cholinesterase which is the enzyme that break Ach down will inhibit further effect

Question 3

Anti-cholinesterase

Answer 3

inhibits the effect of the cholinesterase enzyme which then prolongs the cholinergic effect

Question 4

what are the two main drugs of indirect cholinergic stimulants ?

Answer 4

neostigmine
Pyridostigmine
(not commonly used in the clinical setting due to neg side effects)

Question 5

three main uses for indirect cholinergic stimulants

Answer 5

• reversal or paralysis inducing drugs
• increasing muscle contraction in MG
• increasing gastric mobility

Question 6

adverse effects

Answer 6

• increase in production of (salivary, lacrimation and mucous)
• increase GI mobility, relaxation of sphincters
• decreased HR, change in rythm, decreased BP
• bronchoconstriction

Question 7

direct acting cholinergic drug ?

Answer 7

methacoline
only current agent in common use
- mimics Ach , stimulates cholinergic receptors until inactivated by cholinesterase

Question 8

administration of methacoline

Answer 8

given via neb
causes bronchoconstriction
airflow is measure before and after administration
used to diagnose asthma severity

Question 9

methacholine adverse effect

Answer 9

muscle constriction in the lungs of diagnosed asthmatic- have a bronchodilator stand-by
have emergency assistance