public health/PPD 2 Flashcards
what is epidemiology?
The study of the frequency, distribution and determinants of diseases and health related states in populations in order to prevent and control disease.
what is incidence?
new cases in a time period
what is prevalence ?
existing cases at a point in time
what is person time and when is it used?
person time is a measure of time at risk
it is used to calculate incidence rate which uses person time as denominator
what is absolute risk?
gives a feel for actual numbers involved
e.g. 50 deaths per 1000 population
what is relative risk ?
risk in one category relative to another
e.g. ration of risk of disease in the exposed to the risk in the unexposed
incidence in exposed divided by incidence in unexposed
e.g. how times ore likely it will occur in the intervention group relevant to the control group
RR= 1 means no difference
RR>1 means the intervention increased the risk of the outcome
RR<1 means the intervention decreased the risk of the outcome
what is attributable risk?
the rate of disease in the exposed that may be attributed to the exposure
e.g. incidence in the exposed minus incidence in unexposed
a type of absolute risk (absolute excess risk)
Why is the attributable risk smaller for Disease A compared with Disease B even though the relative risk is much larger?
because disease B is more common
what is relative risk reduction ?
RRR is the reduction in rate of the outcome in the intervention group relative to the control group
what is absolute risk reduction?
ARR is the absolute difference in the rates of events between the two groups and gives an indication of the baseline risk and intervention effect
what is the number needed to treat?
NNT tells us the number of patients we need to treat to prevent one bad outcome
1 over the absolute relative risk
if a study finds an association between an exposure and an outcome, this could be due to:
bias chance confounding reverse causality a true casual association
what is bias?
Asystematic deviation from the true estimation of the association between exposure and outcome
–i.e. a systematic errorwhich leads to a distortion of the true underlying association
what are the main groups of bias?
selection bias (a systematic error in: the selection of study participants, the allocation of participants to different study groups)
Information (measurement) bias - a systematic error in the measurement or classification of exposure or outcome
what are the sources of information (measurement) bias?
observer (observer bias)
participant (recall bias)
instrument (wrongly calibrated instrument)
what is confounding?
The situation where a factor is associated with the exposure of interest and independently influences the outcome (but does not lie on the causal pathway)
when thinking about association and causation what should you consider?
bias
chance
confounding
criteria for causality
what is reverse causality?
This refers to the situation when an association between an exposure and an outcome could be due to the outcome causing the exposure rather than the exposure causing the outcome.
what are the criteria for causality?
Criteria for causality (Bradford-Hill criteria
Strength of association – the magnitude of the relative risk
Dose-response - the higher the exposure, the higher the risk of disease
Consistency – similar results from difference researchers using various study designs
Temporality – does exposure precede the outcome
Reversibility (experiment) – removal of exposure reduces risk of disease
Biological plausibility - biological mechanisms explaining the link.
Coherence – logical consistency with other information
Analogy – similarity with other established cause-effect relationships
Specificity – relationship specific to outcome of interest
what are person years?
measure of time at risk, i.e. time from entry to a study to (i) disease onset, (ii) loss to follow-up or (iii) end of study. Used to calculate incidence rate which uses person time as the denominator.
what are the different types of health behaviours?
a health behaviour - a behaviour aimed to prevent disease (eating healthy)
an illness behaviour - a behaviour aimed to seek remedy (e.g. going to the doctor)
a sick role behaviour - any activity aimed at getting well (taking medications, resting)