PUBLIC HEALTH & MISC Flashcards
according to the GMC, in England, Wales and Northern Ireland, under what age can a child consent to but not REFUSE tx?
16 (parents can over-rule refusal)
in Scotland, if a competent young person <16 refuses treatment, can their parents override this?
no
what are the 5 national screening programmes provided by the NHS?
- diabetic eye
- cervical cancer
- breast cancer
- bowel cancer
- AAA
NHS screening - from what age and how often are these screenings offered?
a) diabetic eye
b) cervical cancer
c) breast cancer
d) bowel
e) AAA
a) all people with diabetes from age 12
b) smear every 3 years aged 25-49 and every 5 years aged 50-64
c) mammogram every 3 years to women aged 50-70
d) FIT test every 2 years aged 50-74
e) once for men when they turn 65
benefits of screening programmes (5)
- may detect problem pre-symptoms
- detecting early = more effective tx
- helps people make more informed decisions about health
- reduce chance of developing a condition/complications
- can prevent some deaths
limitations of screening programmes (6)
- not 100% accurate e.g. false -ve, +ve
- can lead to difficult decisions e.g. screening for abnormalities in pregnancy
- health anxiety
- can still go on to develop condition if result is negative
- biases - selection, lead time, length time
- exposure of well individuals to distressing/harmful diagnostic tests e.g. colonoscopies for +ve faecal occult BT
define these biases present in screening:
a) selection bias
b) lead time bias
c) length time bias
a) those who show up to screen may be at a lower risk of a condition e.g. women in higher SE group more likely to attend cervical/breast screening
b) survival time appears longer because the diagnosis was done earlier (ie by screening), irrespective of whether pt lived longer. apparent increase in survival time even if screening has no effect on outcome
c) overestimation of survival duration due to relative excess cases detected in screening that are asymptomatically slowly growing - fast progressing symptomatic cases less likely to be detected in screening (but on the surface appears that screening results in cancers with better prognosis!)
explain what is meant by:
a) true positive
b) false positive
c) true negative
d) false negative
a) disease present, positive result
b) disease absent, positive result
c) disease present, negative result
d) disease absent, negative result
define and show the calculation for
a) sensitivity
b) specificity
a) proportion of people with disease who are correctly identified by a test (true positives / true positive + false negatives)
b) proportion of people without the disease who are correctly excluded by screening (true negatives / true negatives + false positives
define
a) positive predictive value
b) negative predictive value
a) proportion of people with a positive test result who actually have the disease (true positives / true positives + false positives)
b) proportion of people with a negative test result who actually don’t have the disease (true negatives / true negatives + false negatives)
case control studies
a type of analytical retrospective study - study of choice for investigating RFs and the development of a disease
takes people with disease, matches them to those without the disease and then studies previous exposure to an agent
e.g. whether environmental exposure Y is associated with the development of X
advantages and disadvantages of case-control studies
advantages - good for rare outcomes (e.g. cancer), quicker than cohort/intervention (as outcome has already happened), can investigate multiple exposures
disadvantages - retrospective so only shows association not causation, difficulties finding controls to match cases, prone to selection and information bias, recall bias
cross-sectional study
study of choice for prevalence - analyses data from population/sub-set at a specific point in time
e.g. interviewing children with cerebral palsy from 8 areas in Europe about their daily life experiences
advantages and disadvantages of a cross-sectional study
advantages
- relatively quick and cheap
- provides prevalence data
- large sample size
- good for surveillance and public health planning
disadvantages
- risk of reverse causality (did outcome of exposure come first?)
- cannot measure incidence
- risk recall bias and non-response
cohort study
prospective - for looking at exposure vs non exposure over time e.g. whether children born via IVF are more likely to suffer from mental disorders in childhood
advantages and disadvantages of a cohort study
advantages
- can FU group with a rare exposure e.g. natural disaster
- good for common and multiple outcomes
- less risk of selection and recall bias
disadvantages
- takes a long time!!
- loss to FU (people dropping out)
- need large sample size
incidence of disease
number of new cases during a specified time period
randomised controlled trial
gold standard prospective study with intervention and control
e.g. can an integrated care programme reduce disability in patients with chronic back pain
advantages and disadvantages of randomised controlled trials
advantages
- low risk of bias and confounding
- can infer causality
disadvantages
- time consuming
- expensive
- specific inclusion/exclusion criteria may mean the study population is different from typical patients
- volunteer bias
what is an ecological study
descriptive/observational study design consisting of case reports or case series studying the population
uses routinely collected data to show trends
advantages and disadvantages of an ecological study
+ve
- few ethical issues
- useful for generating hypothesis
- uses routine data so quick and cheap
- shows prevalence and association
-ve
- cannot show causation
- bias: variation in diagnostic criteria
types of information bias
a) measurement
b) observer
c) recall
d) reporting
a) e.g. different equipment used to measure the outcome in different groups
b) e.g. the researcher knows which participants are cases and which are controls, subconsciously reports/measures outcome differently
c) events that happened in the past are not remembered and reported accurately
d) respondents report inaccurate info because they are embarrassed or feel judged
confounding bias
estimated relationship between exposure and outcome is distorted because of the association of the exposure with another factor (confounder) that is also independently associated with the outcome
reverse causality
outcome causing exposure rather than exposure causing outcome
bradford-hill criteria of causality (what makes causality more likely?)
- strength - stronger association between the exposure and outcome
- consistency - same result observed from various studies and in different geographical settings
- dose-response - increased risk of outcome with increased exposure
- temporality - exposure occurs prior to outcome
- plausibility - reasonable biological mechanism
- reversibility - intervention to reduce/remove exposure eliminates or reduces outcome
- coherence - logical consistency with other information
- analogy - similarity with other established cause-effect relationships
- specificity - relationship specific to outcome of interest
purpose of screening
identify apparently well individuals who have (or are at risk of developing) a particular disease so that you can have a real impact on outcome
NHS criteria for a screening test - the condition (4)
- the condition should be an important health problem
- the epidemiology and natural history of the condition should be understood and there should be a detectable RF
- all cost-effect primary prevention interventions should have been implemented as far as practicable
- if the carriers of the mutation are identified as a result, the natural history of people with this status should be understood (including psychological complications)
NHS criteria for a screening test - the screening programme (2)
- screening should be ongoing and not just performed on a “one-off” basis
- the costs of screening should be economically balanced
NHS criteria for a screening test - the test (5)
- simple, safe, precise and validated
- distribution of test values should be known, suitable cut-off defined and agreed
- acceptable to population
- an agreed policy on further diagnostic investigations
- if it’s testing for mutations, criteria for subset of mutations to be covered by screening should be clearly set out e.g. neonatal CF screening- only commonest mutations screened for
NHS criteria for a screening test - the treatment (3)
- effective tx/intervention for patients identified
- policy on whom to treat as patients
- clinical management of condition and patient outcomes should be optimised
3 approaches to a health needs assessment
- epidemiological approach
- corporate approach
- comparative approach
epidemiological approach of a health needs assessment:
a) what sort of data is used?
b) sources of data?
a) - disease incidence & prevalence
- morbidity and mortality
- life expectancy
- services available
b) disease registry, hospital admissions, GP databases, mortality data, primary data collection (e.g. postal/patient survey)
advantages and disadvantages of the epidemiological approach to a health needs assessment
advantages
- uses existing data
- provides data on disease incidence/mortality/morbidity etc
- can evaluate services by trends over time
disadvantages
- quality of data is variable
- data collected may not be the data required
- doesn’t consider felt needs/opinions/experiences