PRIMARY CARE - cardio, resp, endocrine, GI, MSK, neuro, infection Flashcards
define primary and secondary HTN
primary - high BP that doesn’t have a known secondary cause (lifestyle, age, genetics)
secondary - high BP caused by another medical condition e.g. Conn’s, kidney disease, hyperthyroidism
describe the pathophysiology of HTN
plaque build up > thickening of vessel wall > narrowing of lumen > builds up vascular pressure
risk factors for hypertension
- diabetes mellitus
- metabolic syndrome
- old age
- physical inactivity
- tobacco + alcohol
- obesity
- diet
- genetics/FMHx
how does HTN present?
normally asymptomatic, found incidentally
1st line investigation for HTN
clinical BP monitoring
1. if BP >140/90 in clinic, recheck on 2-3 occasions
2. if persistently high, offer ABPM (24hr) or HBPM if ambulatory not tolerated
3. if stage 1 - QRISK to decide tx
4. if stage 2 - start antihypertensive tx
investigations once ABPM has confirmed high blood pressure
look for target organ damage…
1. ECG
2. urine - ACR and dip for haematuria
3. bloods - U&Es, HbA1c, cholesterol, HDL
4. fundoscopy
what is assessed once BP readings and further investigations have been completed?
CV risk - with QRISK
what are the stages of hypertension (ABPM/home average)?
stage 1 (prehypertension) - between 135/85 and 140/90
stage 2 - between 150/95 and 160/100
what is normal BP?
90/60 - 120/80
QRISK
1) what is it?
2) what does it involve?
3) what score is low, medium and high risk?
1) calculates a person’s risk of developing a heart attack OR stroke in the next 10 years
2) RFs like age, sex, smoking, diabetes, angina/heart attack in 1st degree relative, CKD, AF, HTN, BMI, RA
3) low risk = <10%, medium risk = 10-20%, high risk = >20%
management of a patient with a QRISK score of:
a) moderate
b) high
a) lifestyle advice changes e.g. stop smoking, diet, reduce alcohol, exercise
b) start tx e.g. statins
hypertension treatment pathway if patient is <55 and not of black African/African-Caribbean family origin
- ACEi or ARB
- ACEi/ARB + CCB OR thiazide-like diuretic
- ACEi or ARB + CCB + thiazide-like diuretic
- confirm resistant hypertension, seek advice or add low-dose spironolactone/alpha blocker/beta blocker
hypertension treatment pathway if patient is >55 or of black African/African-Caribbean family origin
- CCB
- CCB + ACEi/ARB OR thiazide-like diuretic
- ACEi/ARB + CCB + thiazide-like diuretic
- confirm resistant hypertension, seek advice or add low-dose spironolactone/alpha blocker/beta blocker
1st line hypertension medication if the patient has diabetes (regardless of age/ethnicity)
ACEi/ARB
target BP after HTN treatment for <80y in
a) clinic
b) ABPM/home avg
a) <140/90
b) <135/85
target BP after HTN treatment for >80y in
a) clinic
b) ABPM/home avg
a) <150/90
b) <145/85
angiotensin-converting enzyme inhibitors (ACEis)
a) examples
b) mechanism
c) side-effects
d) contraindications
a) ‘-IL’ e.g. ramipril
b) blocks angiotensin-converting enzyme from converting angiotensin I to angiotensin II (a vasoconstrictor hormone)
c) hypotension, dry cough
d) pregnancy
angiotensin receptor blockers (ARBs)
a) examples
b) mechanism
c) side-effects
d) contraindications
a) ‘-sartans’ e.g. candesartan
b) bind to and inhibit the angiotensin II type 1 receptor > block formation of angiotensin II (vasoconstrictor)
c) hypotension, hyperkalaemia
d) pregnancy
calcium-channel blockers (CCBs)
a) examples
b) mechanism
c) side-effects
d) contraindications
a) ‘-pine’ e.g. amlodipine, felodipine
b) blocks calcium channels in heart and arteries > prevents Ca2+ causing strong contractions > allows vessels to dilate
c) peripheral vasodilation: flushing, headache, oedema. Negatively chronotropic (slows heart): bradycardia. Constipation (gut CCs)
thiazide-diuretics
a) examples
b) mechanism
c) side-effects
d) contraindications
a) ‘-mide’ e.g. indapamide
b) promote diuresis (urine output) > removes excess fluid
c) hypotension, hypokalaemia, hyponatraemia, impaired glucose tolerance, hypercalcemia, postural hypotension
d) pregnancy
define GORD
complications due to the reflux of gastric contents into/beyond the oesophagus, via the lower oesophageal sphincter
aetiology of GORD
weakening of the oesophageal sphincter, due to…
1. lower oesophageal sphincter hypertension
2. hiatus hernia
risk factors for GORD
- obesity
- fatty foods
- smoking + alcohol
- coffee
- chocolate intake
- pregnancy
- hiatus hernia
- certain medications e.g. NSAIDs
pathophysiology of GORD
- reduced tone of lower oesophageal sphincter (LOS) > increased transient LOS relaxations
- LOS relaxes independently of swallowing
- allows gastric acid etc to flow back up
- reflux of acid, bile, pepsin and pancreatic enzymes
- oesophageal mucosal injury