PTH Flashcards
Actions of PTH (4)
Release Ca form bone, Reabsorb Ca in kidneys, Absorb C and P in small intestine, synthesize Vit D
Phosphate excretion increased by..
PTH, PTHrP, hypercalcemia, hypokalemia, hypoagnesemia, calcitonin, glucocorticoids, diuretics
Actions of Vitamin D
Increases intestinal absorption of calcium and stimulates osteoclasts
Labs for PTH (Ca, PTH, P, urine Ca)
High Ca, elevated or normal PTH, low phosphorus, elevated urine Ca
Tx of primary hyperPTH
hydration, ambulation, moderate Ca intake, bisphosphonates, calcimimetics (alters calcium sensing receptor)
Tx of hypercalcemia
increase fluid intake, moderate Ca diet, bisphosphonates, calcitonin, corticosteroids
Mechanism of action: Bisphosphonates
inhibit osteoclastic bone resorption
Types of bisphosphonates (5)
Pamidronate, zoledronic acid, alendronate, risedronate, ibandronate
Mechanism of action: Calcitonin
Increases urinary calcium excretion, inhibits bones resorption; normally secreted by C cells of thyroid
SE’s of Calcitonin
Tachphylaxis
Labs for secondary hyperPTH
low Ca, high Ph, high PTH, low VitD
Tx of secondary hyperPTH
Low Ph diet, Ph binders, VitD replacement
Labs in renal failure induced hypocalcemia
Low Ca, high Ph, PTH and Cr
Phosphate binders (3)
calcium carbonate, calcium acetate, sevelamer
VitD replacements (3)
calcitriol, paracalcitol, doxercalciferol