PTH Flashcards

1
Q

Actions of PTH (4)

A

Release Ca form bone, Reabsorb Ca in kidneys, Absorb C and P in small intestine, synthesize Vit D

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2
Q

Phosphate excretion increased by..

A

PTH, PTHrP, hypercalcemia, hypokalemia, hypoagnesemia, calcitonin, glucocorticoids, diuretics

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3
Q

Actions of Vitamin D

A

Increases intestinal absorption of calcium and stimulates osteoclasts

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4
Q

Labs for PTH (Ca, PTH, P, urine Ca)

A

High Ca, elevated or normal PTH, low phosphorus, elevated urine Ca

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5
Q

Tx of primary hyperPTH

A

hydration, ambulation, moderate Ca intake, bisphosphonates, calcimimetics (alters calcium sensing receptor)

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6
Q

Tx of hypercalcemia

A

increase fluid intake, moderate Ca diet, bisphosphonates, calcitonin, corticosteroids

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7
Q

Mechanism of action: Bisphosphonates

A

inhibit osteoclastic bone resorption

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8
Q

Types of bisphosphonates (5)

A

Pamidronate, zoledronic acid, alendronate, risedronate, ibandronate

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9
Q

Mechanism of action: Calcitonin

A

Increases urinary calcium excretion, inhibits bones resorption; normally secreted by C cells of thyroid

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10
Q

SE’s of Calcitonin

A

Tachphylaxis

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11
Q

Labs for secondary hyperPTH

A

low Ca, high Ph, high PTH, low VitD

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12
Q

Tx of secondary hyperPTH

A

Low Ph diet, Ph binders, VitD replacement

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13
Q

Labs in renal failure induced hypocalcemia

A

Low Ca, high Ph, PTH and Cr

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14
Q

Phosphate binders (3)

A

calcium carbonate, calcium acetate, sevelamer

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15
Q

VitD replacements (3)

A

calcitriol, paracalcitol, doxercalciferol

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16
Q

Labs in hypoPTHism

A

low calcium, low PTH, high Ph

17
Q

Tx goals of hypoPTHism

A

normalize Ca and Ph, avoid hyperCa

18
Q

Tx for osteoporosis

A

Bisphosphonates (Alendronate, risedronate, ibandronate), Selective estrogen receptor modulates (Raloxifene), Calcitonin (not used anymore), Teriparatide, Denosumab

19
Q

Raloxifene

A

SERM used to tx osteoporosis

20
Q

SE’s of bisphosphonates

A

GI irritation, administration restrictions

21
Q

Teriparatide

A

PTH analog. Exposure of short daily bursts stimulates bone resorption and formation; Used to tx osteoporosis. SEs: dizziness, palpitations, transient hypercalcemia

22
Q

Denosumab

A

RANKL inhibitor

23
Q

Does OPG increase or decrease bone resorption?

A

Decrease

24
Q

Which decreases Ca bound to albumin (and therefore increases free ionized Ca): Alkalosis or Acidosis

A

Acidosis

25
Q

MC sites of Ca reabsorption in kidneys

A

PT and loop of Henle

26
Q

Resorption of renal Ca is enhanced by…

A

PTH, phosphate, metabolic alkalosis, thiazide diuretics, increased Na resorption

27
Q

Excretion of renal Ca is enhanced by…

A

metabolic acidosis, loop diuretics, saline diuresis and PTH deficiency

28
Q

Renal reabsorption of Ph is enhanced by…

A

phosphate depletion, hyPOparathyroidism, hyPOcalcemia

29
Q

Renal excretion of Ph is enhanced by…

A

PTH, PTHrP, hypercalcemia, hypokalemia, hypomagnesemia, glucocorticoids, calcitonin and diuretics

30
Q

Triad of Multiple Myeloma

A

Hypercalcemia, anemia, renal insufficiency

31
Q

Causes if secondary hyperparathyroidism

A

phosphate retention and lack of 1-a-hydroxylase activity in failing kidneys