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Endocrine Pharm > KAPLAN Antithyroid > Flashcards

KAPLAN Antithyroid Flashcards

1
Q

Steps or Thyroid Hormone synthesis

A
  1. Accumulation of iodine into gland
  2. Oxidation of iodide—peroxidase—-> iodine
  3. Organification: Iodination of tyrosyl residues on TG–> MIT and DIT
  4. Coupling of MIT and DIT–> T3 and T4
  5. Release of T3 and T4 from TB
  6. Conversion of T4—5’deiodinase–>T3
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2
Q

How to block accumulation of iodine into gland

A

selective cell destruction by 131 I

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3
Q

How to block oxidation of iodide–>iodine

A

Thioamides

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4
Q

How to block organification of TG

A

Thioamides

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5
Q

How to block coupling of MIT and DIT

A

Thioamides

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6
Q

How to block release of T4 and T3

A

high doses of iodide

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7
Q

How to block conversion of T4–>T3

A

Propranolol and PTU

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8
Q

Types of Thioamides

A

PTU (better in pregnancy) and Methimazole

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9
Q

Mechanism of action: Thioamides

A

inhibits thyroid peroxidase

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10
Q

Mechanism of action: Iodide

A

feedback inhibits TRH release–> decreases gland size, fragility and vascularity. NO long term use

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Endocrine Pharm (7 decks)

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