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Endocrine Pharm > Kidney Transplant > Flashcards

Kidney Transplant Flashcards

1
Q

Steps of immunosuppression in kidney transplant

A

Induction- stuns immune system
Maintenance- light reign on immune system
Antirejection- spank system back in line

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2
Q

Anti-IL-2 receptors Antibodies (2)

A

Dacluzimab and Basiliximab

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3
Q

What do calcinurin inhibitors do?

A

block IL-2 production

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4
Q

What are the 2 main categories of calcinurin inhibitors?

A

Cyclosporin and Tacrolimus

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5
Q

What steroids are used for immunosuppression?

A

Methylprednisoloine, prednisone

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6
Q

What do antimetabolites do?

A

inhibits de novo purine synthesis

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7
Q

What are the 3 main antimetabolites?

A

Azathioprine, mycophenolate mofetil, mycophenolic acid

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8
Q

What types of drugs are used in induction?

A

Antibodies and methylprednisolone

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9
Q

What types of drugs are used in maintenance?

A

Calcinurin inhibitors, steroids, antimetabolites, mTOR inhibitors, Belatacept

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10
Q

What are the main mTOR inhibitors?

A

Sirolimus, Everolimus

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11
Q

What is Belatacept?

A

Fusion protein of IgG1 and the extracellular domain of CTLA-4

Blocks co-stimulation of T cells by preventing CD28-CD80/86 interaction

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12
Q

What are the two approaches to anti-rejection therapy?

A

Preventing cell-mediated rejection and antibody-mediated rejection

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13
Q

What can be used to prevent cell mediated rejection?

A

pulse steroids and thymoglobulin

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14
Q

What can be used to prevent antibody-mediated rejection?

A

rituximab, plasmapheresis, IVIg

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15
Q

SEs of Antibodies

A

Lymphopenia, cytokine release syndrome

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16
Q

SEs of steroids

A

weight gain, glucose intolerance, hyperlipidemia, hypertension, osteoporosis, avascular necrosis, cataracts

17
Q

SEs of Calcinurin inhibitors

A

nephrotoxicity, gingival hyperplasia, hypertrichosis, hyperlipidemia, tremor, neuropathy, hyerpuricemia/gout, glucose intolerance, HUS

18
Q

SEs of azathioprine

A

leukopenia/myelosuppression, hepatotoxicity, pancreatic toxicity, interactions with allopurinol

19
Q

SEs of mycophenolate

A

GI intolerance, leukopenia/myelosuppression

20
Q

SEs of sirolimus

A

hyperlipidemia, impaired wound healing, interstitial pneumonitis

Endocrine Pharm (7 decks)

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