PTA Flashcards
What are the different forms of Asthma?
- Allergic
- Non-allergic (exercise induced etc)
- Late onset asthma (in adult life)
- With fixed air flow limitation (due to airway remodelling)
- With obesity
How many people in NL suffer from Asthma?
1.8 million
Is Asthma more prevalent in men or women?
Women
What does IgE in Asthma stand for?
Immunoglobulin E
(an antibody generated by the immune system in response to a harmless stimulus)
What happens during the first contact with an allergen in Asthma?
- IgE production by eusoniphil leucocytes starts
- IgE attaches to mast cell
→ No symptoms
What happens during the second contact with an allergen in Asthma?
- Allergen binds to IgE molecules (which are now attached to mast cell)
- Mast cell gets activated/degranulated
- Histamine is released → causes allergic reaction
What are the characteristics of a non-allergic asthmatic reaction?
- Non-specific stimulus like effort, smoke, dust, fog, cold, viral infection, stress is present
- Degranulation of mast cell and release of histamine without involvement of IgE
Exercise-induced bronchoconstriction is the case in?
Exercise induced asthma
What can absence of wheezing in asthma patients indicate?
Exacerbation! Silent chest
How can asthma best be treated?
Minimising future risk of:
- Exacerbation
- Fixed airflow limitation
- Side-effects of medication
- Immediately decreased risk of cardiorespiratory problems by 50%
- Decrease of cholesterol after 1 week
- Decrease of blood pressure by 10mmHg
- Decrease of pulse by 10-25 bpm
- Decreased risk of infection
- Decrease in adrenaline production
These are benefits of eliminating which risk factor?
Smoking
The risk for cardiac pathology equals non-smokers when?
2-3 years after quitting smoking
Cholesterol decrease of 10% lowers the risk of cardiac pathology by?
20%
Total cholesterol should be?
190mg/dL or 5mmol/L or below
LDL should be?
150mg/dL or 3,9mmol/L or below
HDL should be?
At least 45mg/dL or 1mmol/L
What are benefits of a normal blood pressure?
- Decreased risk of cardiovascular pathology
- Decreased risk of kidney problems
- Decreased risk of stroke
- Decreased load on the heart
Goals of cardiac rehab are?
→ Prevention / treatment of pulmonary complications
→ Treatment of risk factors
→ Improve and maintain exercise capacity
→ Improve quality of life
What are the phases of cardiac rehab?
- Preoperative phase
- Phase 1 or clinical phase
- Phase 2 or rehabilitation phase
- Phase 3 or post-rehabilitation phase
When does the preoperative phase of cardiac rehab start?
4 weeks before surgery
What is the frequency and duration of sessions in the preoperative phase of cardiac rehab?
7 days per week
20min per session
What aspects are trained in the preoperative phase of cardiac rehab?
- Inspiratory muscle training (IMT) with threshold device
- Breathing exercises
- Airway clearance techniques
Which patients have to do the preoperative phase of cardiac rehab?
Open heart surgery patients
(coronary artery bypass grafting CABG and/or valve replacement)
→ with increased risk of developing pulmonary complications post-operative
When does phase 1/clinical phase of cardiac rehab start?
Immediately after acute cardiac event
What are the main compartments of phase 1/clinical phase of cardiac rehab?
- In acute phase → relative rest with pulmonary physiotherapy
- Afterwards mobilisation phase at the hospital
- Dynamic mobilisation as early as possible
- Gradual build up and inclusion of ADLs like walking and stair climbing
When can you progress to phase 2/rehabilitation phase of cardiac rehab?
→ Patient is able to execute the intended ADLs (also with assistance)
→ Moderate exertion (3-4 MET) is possible
→ Patient has some knowledge of the heart disease
→ Patient is able to cope with condition and can increase ADL capacity
Where does phase 2/rehabilitation phase of cardiac rehab take place?
Almost always out-patient
What are the main components of phase 2/rehabilitation phase of cardiac rehab?
→ Practice functional skills
→ Develop enjoyment of exercise
→ Improve aerobic endurance
→ Improve strength and strength endurance
How often should strength training and endurance training be applied in phase 2/rehabilitation phase of cardiac rehab?
2-3 times per week EACH
What are the main characteristics of phase 3/post-rehabilitation phase of cardiac rehab?
- Carried out outside of institutional health care
- Focus on maintaining active life style initiated in phase 2
- Patient maybe advised to join exercise programme in primary care
- Check up 6-12 months after phase 2 has ended
Which scales can be used in cardiac patients?
Dyspnea scale
Borg scale
Angina pectoris scale
What are the 4 classes on the angina pectoris scale?
Class 1 - Angina only during strenuous and prolonged physical activity
Class 2 - Slight limitation, with angina only during vigorous physical activity
Class 3 - Moderate limitation, angina symptoms in ADLs
Class 4 - Severe limitation, inability to perform any activity without angina or angina at rest
What is the range of the dyspnea scale?
0-10
0 = nothing at all
10 = maximal
What are main characteristics of atherosclerosis?
- Not the same as arteriosclerosis
- Accumulation of fat-like substances, CT and calcium on inner wall (endothelium) of artery → Atheroma
- Accumulation of LDL → low-density lipoprotein, HDL can reduce this (high-density lipoprotein
How does atherosclerosis develop?
→ Nitric oxide (NO) is synthesised to protect endothelium against accumulation of fat
→ Increased consumption of bad saturated fat increases oxidative stress and inhibits protective function of NO
→ Plaque accumulates
What can be typical consequences of atherosclerosis?
Thrombosis
Infarction
Aneurysm
Pulmonary Embolism
What are typical symptoms of an infarction?
→ Tight and pressing pain in the centre of the chest
→ Possible radiation to arm, neck, jaw, back or stomach
→ Sweating, nausea, vomiting
What is the mechanism of pulmonary embolism?
- Thrombus/embolus gets trapped in small vessel
- Repetitive embolisms lead to reduction in pulmonary vascular bed
- Pulmonary hypertension develops
What are typical symptoms of pulmonary embolism?
→ Shortness of breath (dyspnoea)
→ Pain with sighing and coughing
→ In combination with emphysema → pulmonary infarction
Dilated veins due to valve disfunction
→ Blood flows back
What is the clinical term for this?
Varicose Veins
What are typical symptoms of varicose veins?
→ Visible tangle of barrels
→ Brown discolouration of skin
→ Swelling of lower leg/ankle (especially after long periods of standing)
→ Lying reduces pressure and swelling
→ Not painful but uncomfortable
How high is the percentage of muscle mass in the body weight of elderly?
25%
What does the TFI (Tilburg Frailty Index) assess?
- Identify fragility at early age → earlier help
- Physical, psychological and social health
- Mapping fragility
→ Increase quality and effectiveness of health care
When does functional ageing often start?
65 years
How many hours a day are elderly >70 usually sedentary?
10h per day
What are the 5 geriatric giants?
→ Falls
→ Incontinence
→ Confusion
→ Impaired homeostasis
→ Iatrogenic disorders (e.g. polypharmacia)
6% loss of muscle mass and 16% loss of strength in elderly are the result of?
10 days of bed rest
What is the definition of polypharmacy?
Use of at least 5 different drugs for different conditions over long period of time
Which tool can be used to assess delirium in elderly?
Use DOS-scale (Delirium Observation Screening)
What is the top injury after a fall in elderly?
hip fracture (17%)
Tinetti Test
Short Physical Performance Battery (SPPB)
Timed Up and Go Test (TUG)
De Morton Mobility Index (DEMMI)
Handgrip Strength Test
Berg Balance Scale
6 Minute Walk Test
What can these clinimetric tools be used for?
Assessment of functional capacity of elderly
Which point range indicates high risk of falling in the Tinetti Test?
≤ 18 points
What does the DEMMI assess?
Mobility and balance in bed, sitting, standing, walking and in dynamic motions
What does the Short Physical Performance Battery (SPPB) test?
gait speed, sitting to standing and balance
65% of Class 4 heart failure patients die within?
12 months
50% of Class 2-3 heart failure patients die within?
5 years
What is the general principle of heart failure?
- Inability to pump the blood through the body properly
- Usually because heart has become too weak or stiff
- Myocardial infarction
- High blood pressure
- Heart diseases (rhythm disorder, valve disorder, poor blood flow, cardiomyopathy)
- Coronary artery disease
- Diabetes mellitus
- Atherosclerosis → Cause for heart attack
- Valve inefficiency → Blood flows back
What can all of these pathologies cause?
Heart failure
What causes shortness of breath in heart failure patients?
- Fluid/oedema in the lungs
- Arteries in the lungs are under high pressure and fluid gets into the lung tissue
- Shortness of breath
- Fluid/oedema in the lungs
- Arteries in the lungs are under high pressure and fluid gets into the lung tissue
- Fatigue
- Oedema (ankles)
- Forgetful
- Poor concentration
- Cold hands
- Poor sleep
- Having to urinate more often during night (build up of fluid in the body)
- Attacks of shortness of breath and coughing when lying flat
- Slow recovery after physical effort
These are typical symptoms of?
Heart failure
Why is sudden weight gain important to check in heart patients?
Holding of fluid/water in the body -> can indicate heart failure
What are red flags in heart failure patients?
- Serious cognitive problems
- Weight gain of > 3kg within a few days, wether or not accompanied by dyspnea at rest
- No limitations in any activities
- No symptoms in ordinary activities
- VO2max > 20ml/kg/min
- MET > 6
- Watt (intensity) > 100
Which heart failure classification according to NYHA is that?
Class 1
- Slight limitations in physical activities
- Comfortable at rest
- Symptoms during moderate physical activity
- VO2max 15-20ml/kg/min
- MET 4-6
- Watt (intensity) 60-100
Which heart failure classification according to NYHA is that?
Class 2
- Marked limitation of physical activity
- Minor activities result in symptoms
- VO2max 10-15ml/kg/min
- MET 3-4
- Watt (intensity) 30-60
Which heart failure classification according to NYHA is that?
Class 3
- Severe limitation of physical activity
- Symptoms at rest
- VO2max < 10ml/kg/min
- MET < 3
- Watt (intensity) < 30
Which heart failure classification according to NYHA is that?
Class 4
What MET score is walking?
3
What MET score is watching TV?
1.5
What MET score is cycling at 12kmh?
5
What are the main therapy goals of heart failure treatment?
→ Maintain condition as good as possible
→ Loose weight (decrease cardiac load)
→ Minimise salt ingestion
→ Restriction of fluid (< 2l per day)
→ Stop smoking
→ Limit alcohol consumption
Which heart failure medication is taken to reduce the pre-load of the heart?
Diuretics like Furosemide, Hydrochlorthiazide
Which heart failure medication is taken to reduce the after-load of the heart?
ACE-inhibitors, vasodilators
Which medication is used for heart failure patients to increase heart contraction force?
Digitalis -> Digoxin
First endurance or interval training in heart failure patients?
First Interval then endurance
What are the endurance session parameters for heart failure patients with VO2max below 17.5ml?
2x 15min sessions per day
How is interval training for heart failure patients build up?
→ 4 x 4min of 80-90% of VO2peak
→ Active recovery 3min of 40-50% of VO2peak in between sets
At what frequency should inspiratory muscle training (IMT) be used in heart failure patients?
- 15-20min
- 3-4 times a week
- 8-12 weeks consecutively
Which heart failure patients should use IMT as an adjunct?
For class II-III with PImax < 70% of predicted value or ventilatory limitations
How is the 1RM in heart failure patients determined?
calculate 10RM
What are the normal strength training parameters for heart failure patients?
- Gradual increase from 40% to 65% of 1RM
- Train large muscle groups
→ 2-3 times a week, 2-3 sets, 10-15reps
How long does the pre-training period for strength training in heart failure patients take and what are the parameters?
2 week pre-training period
→ 2-3 sets, 10 reps, < 30% of 1RM
→ Venipuncture
→ Limb constriction
→ Limb elevation
→ Heat/cold application or surrounding
→Air travel and use of compression garments when travelling by air
Is there weak or strong evidence that the above provoke or treat lymphoedema?
Weak evidence
What are good ways to prevent lymph oedema according to research?
→ Maintaining a normal body weight, normal BMI
→ Participation in supervised exercise programme
What are the 3 types of oedema?
→ Venous oedema
→ Lip-oedema
→ Lymphoedema
→ Painful, swollen feelings in the legs
→ Cold feeling
→ Increasing complaints during the day
→ Tiredness
→ Foot, knee and hip complaints
These are typical symptoms of?
Lip-Oedema
- Large amounts of irregularly distributed fat
- Mainly hips, thighs and lower legs
- Mainly women affected
- Heredity may play a role
These are typical characteristics of?
Lip-Oedema
→ Heavy, restless feeling in the legs
→ Swollen ankles and legs
→ Varicose veins
→ Eczema: Brown or white skin discolouration
These are typical symptoms of?
Venous Oedema
- Faulty valves in veins
- Impaired return of oxygen-poor blood from legs to heart
These are typical characteristics of?
Venous Oedema
→ Swelling
→ Fatigue and heaviness
→ Pain
→ Limitations in movement and daily functioning
→ Skin abnormalities and infections
These are typical symptoms of?
Lymphoedema
- Abnormal accumulation of tissue fluid
- Malfunction of lymph system:
- Too little vessels
- Damage of lymph vessels or nodes
- Overload of lymph system
These are typical characteristics of?
Lymphoedema
- Clothes, jewellery and watches become too tight
- Increasing unilateral or bilateral limb circumference
- Dimple in skin after pressure
- Differences in skin thickness
These are good ways to recognise?
Oedema
What are risk factors for oedema?
- Inactivity
- Obesity
- Infections (erisepelas)
What are typical causes for oedema?
- Lymphatic system
- Blood vessels
- Fat
- Heart
- Kidneys
- Genetic factors
→ Often a combination
How much percent of yearly deaths worldwide are related to NCDs?
71%
How much percent of all yearly NCDs related deaths are due to high BP?
12.8%
What is the cut off for high BP?
140/90mmHg
What is a normal cholesterol level in the blood?
5.0mmol/L or 190/200mg/dL
Which cholesterol level increases the chances of atherosclerosis by 4 times?
> 8.0mmol/L or 300mg/dL
How much does co-smoking increase the risk of lung cancer or cardiovascular diseases ?
20-30%
What is a normal blood sugar level?
4.0-8.0mmol/L or
What are typical symptoms of Hypoglycaemic?
→ Sleepiness
→ Sweating
→ Pallor
→ Lack of coordination
→ Irritability
→ Hunger
What are typical symptoms of Hyperglycaemia?
→ Dry mouth
→ Increased thirst
→ Blurred vision
→ Weakness
→ Head ache
→ Frequent urination
What is the optimal body fat % for men and women?
Men <20%
Women <30%
What is the optimal waist size for men and women?
Men <102cm
Women <88cm
What is the optimal BMI?
18.5 - 24.9
- Increase of HR and BP
- High caloric density
- Increased risk of cancer
- Negative effects on fats and HDL
- Production of toxins in liver (acetaldehyde)
- Negatively effects BP drugs
- Bad eating habits
These are negative effects of consuming?
Alcohol
- Patients with heart failure
- Patients with congenital heart defect
- Patients with heart transplant
- Patients with defribrillator (ICD) or pacemaker
- Patients with arrhythmias
- Patients with atypical thoracic pain complaints (heart anxiety)
- Patients with resuscitation or cardiothoracic surgery
- Patients with left ventricular assist device (LVAD)
These are relative or normal indicators for cardiac rehab?
Relative indicators
- Based on coronary artery disease
- Patients with acute coronary syndrome (ACS) (including infarction AMI and unstable angina pectoris)
- Patients with stable angina pectoris
- Patients who have undergone percutaneous coronary intervention (PCI)
- Patients who have undergone coronary artery bypass grafting (CABG) or valve surgery
These are relative or normal indicators for cardiac rehab?
Normal indicators
Psychological stress can cause?
- Fatigue
- Pain
- Decreased motor control
- Decreased blood flow in the muscles
What are synonyms for sPAD (Symptomatic Peripheral Arterial Disease)?
“Intermittent Claudication”
“Window Shopping Disease”
How many people over 55 suffer from sPAD worldwide?
19% (200 million worldwide)
What is the life expectancy with sPAD?
< 10 years
- Narrowed arteries due to plaque (especially at branches)
- Endothelial membrane impaired
- Insufficient oxygen supply to muscles
This is the typical mechanism of which disease?
sPAD
- Pain in lower extremities distal to stenosis
- Walking provokes pain
- Standing and pausing reduces complaints
- Skin defects
- Colour and/or temperature differences
- Muscle weakness
- Sensory disorders
These are typical symptoms of?
sPAD
According to Fontaine sPAD can be categorised in?
5 classes
I - Asymptomatic
IIa - Mild claudication
IIb - Moderate to severe claudication
III - Rest pain
IV - Ulceration or gangrene
According to Rutherford sPAD can be categorised in?
7 classes
0 - Asymptomatic
1 - Mild claudication
2 - Moderate claudication
3 - Severe claudication
4 - Rest pain
5 - Minor tissue loss
6 - Severe tissue loss or gangrene
- Walking Impairment Questionnaire (WIQ)
- Cumulative Illness Rating Scale (CIRS)
- Quality of Life (EQ-5D)
- BORG-scale
- ACSM-scale
- Perceived Stress Scale (PSS)
These are typical clinimetric tools for the assessment of?
sPAD
What is the protocol of the graded treadmill test for sPAD?
- Speed at 2mph or 3.2kmh
- Start with altitude of 0°
- Increase altitude by 2° every 2 minutes → Until 10° is reached
- Max duration of test 30min
- Note time and distance:
→ when patient wants to stop (functional walking distance)
→ when patient has to stop (max walking distance) - Use ACSM score
- Use as evaluative tool in treatment
What is the ACSM score in the assessment of sPAD?
Grade 1: Light discomfort or onset of pain on modest level (present, but minimal)
Grade 2: Moderate discomfort or pain of which the patient’s attention can be diverted (e.g. by conversation)
Grade 3: Intense pain (almost grade 4) from which the patient’s attention can’t be diverted
Grade 4: Excruciating and unbearable pain
What does ACSM stand for?
American College of Sports Medicine
What is the outcome of the ABPI/ABI - Ankle Brachial Pressure Index?
→ Dividing the systolic BP at dorsal pedis artery or posterior tibial artery (choose highest) by brachial BP
- Normal ABI: 1.0-1.4 (pressure in ankle is normally higher than in arm)
- ABI 0.9 or below? → Positive Test!!
- ABI below 0.5? → Severe PAD
→ Insufficient blood flow to heal wounds - ABI above 1.4? → Calcification of blood vessel (diabetes or elderly people)
When is the ABI positive for sPAD?
0.9 or below
How long does the maintenance phase of sPAD rehab take?
40 weeks
How long does the start phase of sPAD rehab take?
4 weeks
How long does the self/training phase of sPAD rehab take?
8 weeks
How are objective limitations in sPAD reduced?
→ Maximise pain-free walking distance
- ACSM of 3-4
- Minimum 6 months → homework
- 3x per week → homework
- Each session 30min → homework
How are subjective limitations in sPAD reduced?
- No pain no gain
- Safe environment
- Recognise limitations ion ADLs
- Recognise and cope with cardiac limitations
→ Have fun being active!!!
What are the main goals of sPAD rehab?
- Improve activities and participation
- Reduce objective and subjective limitations
- Reduce risk factors of arteriosclerosis
- Education and promotion of healthy lifestyle
- Improve quality of life
What happens after 3-6 months according to the stepped care model?
evaluation of treatment
Continue therapy or referral to surgeon
What is the KomPas Tool?
Tool for shared decision making
What are the main tasks of claudicationet or chronisch zorgnet?
treatment and monitoring of NCDs eg intermittent claudication
Autogenic training / self-hypnosis for relaxation was invented by?
Johannes Schultz
Relaxing the body by contracting and relaxing certain muscles are the key components of which technique ?
Progressive muscle relaxation by Jacobson
Which amount of smokers will develop COPD?
40-50%
How many COPD patients used to smoke or still smoke?
75%