Psychotic disorders Flashcards

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1
Q

What are the neural bases for psychotic disorders?

A

reduced regional brain volume, enlarged cerebral ventricles, reduced limbic regions, dopamine function

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2
Q

What are some of the identified risk factors for schizophrenia?

A

low SE status, low IQ, perinatal factors, cannabis use

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3
Q

Distinguish positive versus negative symptoms of schizophrenia

A

positive - hallucinations,

negative - lack of motivation, poor self care, alogia, asociality

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4
Q

What are the medications used to treat schizophrenia?

A

antipsychotics, psychosocial support

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5
Q

What is schizoaffective disorder and how is it different from schizophrenia?

A

have symptoms of schizophrenia plus major mood disturbance. psychotic features persist 2 weeks after mood symptoms resolve

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6
Q

What is the treatment for schizoaffective disorder?

A

antipsychotics plus mood stabilizers

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7
Q

What is schizophreniform disorder?

A

schizophrenia that lasts 6 months and does not involve social withdrawal

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8
Q

What is delusional disorder?

A

non-bizarre delusions without psychotic symptoms, typically long term and non-remitting

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9
Q

What populations seem to be at risk for delusional disorder?

A

women, migratory patterns, paranoid

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10
Q

What are the treatments for delusional disorder?

A

psychotherapy

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11
Q

What is the definition of a brief psychotic episode?

A

psychotic symptoms lasting 1 day to 1 month

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12
Q

When can brief psychotic episodes occur?

A

post partum, post stressor

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13
Q

What medical conditions should be considered for psychosis?

A

CNS disease, Addison’s/Cushings, B12/folate,

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14
Q

What are the DSM IV criteria for schizophrenia?

A
2 or more for at least 1 month:
- delusions
- hallucinations
- disorganized speech
- catatonia
- negative symtpoms
Only 1 required if delusions are a running voice
Duration of symptoms more than 6 months not allowed
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15
Q

What are the different types of schizophrenia?

A

Paranoid, disorganized (disorganized speech, poor functioning, early onset) catatonic (rare, echolalia and echopraxia present) residual (prominent negative symptoms)

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16
Q

Describe epidemiology for schizophrenia

A

More common among those born in winter, men at 20, women at 30
Post psychotic depression
Substance abuse common
Very strong genetic predisposition

17
Q

What is folie a deux?

A

Shared psychotic disorder when patient develops same delusional symptoms

18
Q

What medications are especially helpful in the treatment of negative symptoms of schizophrenia?

A

clozapine, olanzepine

19
Q

What medications can increase schizophrenia medication compliance?

A

injectable haloperidol

20
Q

What medication can be useful in treating tardive dyskinesia?

A

clozapine

21
Q

What is the rate of suicide in schizophrenics?

A

10%

22
Q

What drugs can induce a psychotic event?

A

amphetamines

23
Q

How does schizophrenia differ in males vs. females?

A

incidence is the same - occurs at earlier age in men; worse prognosis in men

24
Q

A patient with schizophrenia presents with hyponatremia - what is the cause?

A

psycogenic polydipsia

25
Q

A man becomes agitated after a period of brooding. this is called…

A

amok

26
Q

A man becomes convinced that his penis is receding into his body. This is called..

A

koro

27
Q

A Brazilian lady presents with depressive and anxiety symptoms. This is..

A

nervios

28
Q

An Indian man presents with weakness, anxiety and is preoccupied by semen discharge. This is..

A

Dhat

29
Q

A Native American man presents with a preoccupation with death. This would be called..

A

ghost sickness

30
Q

What symptom is most specifc for schizophrenia?

A

bizarre delusions

31
Q

What is the lifetime risk of suicide in schizophrenics?

A

10%

32
Q

What are the soft neurological signs associated with schizophrenia?

A

Sensory gating issues, decreased ability to habituate to repeated stimuli

33
Q

What is palinopsia?

A

Sense of object remaining even after stimulus removed

34
Q

What is one of the advantages of aripiprazole compared to other atypcal antipsychotics?

A

less likely to cause weight gain

35
Q

What is the neurological correlate of schizophrenia?

A

lateral ventricular enlargement