Psychoactive Drugs Flashcards
Agonists
A molecule that increases a neurotransmitters actions by increasing the production or release of neurotransmitters due to the mimicry of an excitatory or inhibitory effect and blocking reuptake
Antagonist
A molecule that inhibits or blocks a neurotransmitters action, blocks effect of receptor site
Depressants
Reduce neural activity and slow body functions, alcohol is the most commonly used and abused depressant in the world
Alcohol
Acts as a disinhibitor, reducing activity in the frontal cortex and slowing neural processing.
- acts as an agonist with inhibitory GABA receptors making them more inhibitory
- disrupts memory impairing REM sleep and reduces self awareness and control
- increases nerve cell death
- can lead to alcohol use disorder
Barbituates
GABA agonist- calming effects
- sedative effects from mild sedation to coma
- highly addictive and if combined with alcohol can be lethal
Benzodiazepines
Drugs that lower anxiety and reduce stress (Xanax)
- depresses heartbeat and breathing
- described as safer and often prescribed
Opioids
Derived from opium poppy (morphine, heroine, oxycontin, methadone)
- similar to depressants, block pain signals snd highly addictive
- agonist for endorphines
- stimulate receptor sites for endorphines
Stimulants
Excite neural activity and speed body functions, increases energy and alertness
caffeine
Naturally occurring mild stimulant, in high does can cause anxiety, insomnia
Nicotine
Highly addictive stimulant found in tobacco products producing a slight rush, can lead to nervousness, irritability, and nausea
Cocaine
Highly addictive stimulant that enters the bloodstream producing a rush. Blocks reuptake and ends in crash.
Amphetamines
- Increases alertness and energy
- synthesized in laboratories to treat ADHD, narcolepsy, and weight gain
- high potential for abuse
Methamphetamines
(Crystal meth, rock, ice)
- faster acting, more potent/dangerous/addictive
- triggers release of dopamines leading to 8 hours of heightened energy but may lead to reduced dopamine levels after leaving users depressed
- leads to irritability, insomnia, hypertension, seizures, depression, and violent outbursts
MDMA
Also known as ecstasy, a stimulant and mild hallucinogen producing feelings of intimacy, can damage serotonin production leaving a permanent deflation of mood and impairment of memory
Marijuana
THC is the major active ingredient, amplifies sensitivity and lingers in body for more than a week, users may achieve high with smaller doses