Psychiatry: PreTest Flashcards
CYP450 medications interactions
-drugs metabolized by CYP450 (e.g. antiretrovirals) can increase levels of psych drugs: -buproprion -meperidine -benzos -SSRIs
Clomipramine: drug category, use
-TCAs -OCD
Leukopenia management with clozapine use
-mild (WBC=3-3.5) +/- sx ==> twice weekly CBCs w/diff -serious (WBC=2-3) ==> daily CBCs and stop clozapine; can restart after CBCs normalize -agranulocytosis ==> stop cloz, isolate, bone marrow sample, cannot restart cloz
Ramelteon =
melatonin agonist
Labs in carbamazepine initiation/monitoring
-@ initiation: CBC, retic count, electrolyes, LFTs, UPT -qmonth x 2, then q3mo.: LFTs
Weight gain with antidepressants
-high: amitriptyline -intermediate: doxepin, nortriptyline, phenelIne -low: sertraline
Use of St. John’s wort
-antidepressant, sedative, anxiolytic
Psych drugs preg. categories
C = ASA, haloperidol, chlorpromazine(antipsych) D = Li, tetracycline, ethanol X = valproic acid, thalidomide
Tx of tardive dyskinesia
- reduce dose or d/c antipsychotic 2. if not possible ==> clozapine
Tx of akithesia
- B-blocker 2. benzo or anticholinergic
Induction agent used in ECT
Methohexital = barbituate w/quick onset/offset
Seizure after flumazenil?
Likely in setting of seizure d/o
TCA side effects
-anticholinergic = urinary retention, blurred vision, constipation, dry mouth -amitryptiline = most anticholinergic
Ritalin SE
-can lead to insomnia
Tx of tourette syndrome
- haloperidol
Anti-depressant choice in elderly
SSRIs > TCAs b/c no anticholinergic or cardiotoxic effects and no orthostatic hypotension
Disulfiram: MOA
inhibits acetaldehyde dehydrogenase
Psychotic sx in parkinsons tx
clozapine = anticholinergic & sparing of nigrostriatial sparing
Non-psych med used to treat depression
levothyroxine
Tx of hyperarousal sx in PTSD
-B-blockers -Clonidine (alpha-agonist)
Characteristics of serotonin discontinuation
-w/abrupt d/c of SSRIs -dizziness, nausea, flu-like, sensory/sleep disturbance -crying spells or irritability -usually 1-3 days after last dose -most common w/paroxetine and sertraline
Tx of cataplexy
Anti-depressants (SSRIs, TCAs, MAOIs) suppress REM sleep and tx cataplexy
Tx of NMS
- d/c antipsychotics 2. correct fluid imbalance, manage pressure, tx fever 3. DA agents: bromocriptene, dantrolene, amantadine
Meds for improving cognitive fxn in Alzheimers
-anti-cholinesterases: -tacrine -donepezil -metrifonate -galantamine