OBGYN UWorld Facts Flashcards
PPD2 w/bilateral breast tenderness, warmth, redness, and tense ==> dx?
- likely breast engorgement
- most common during first 24-72h after delivery due to milk accumulation
- usually resolves @ 3-5 days
- tx = cool compresses, anti-inflammatory
Mastitis presentation
- fever
- unilateral, isolated area of warmth, redness, tenderness on breast
- due to plugged milk ducts + infection
- tx = anti-staphylococcal agents
Sheehan syndrome presentation
- ischemic necrosis (usually associated w/peri-partum bleeding) ==> hypopituitarism
- hypopituitarism ==>
- decreased prolactin ==> lactation failure
- hypothyroidism ==> lethargy, weight gain,etc.
- hypogonadism/amenhorrhea
Common causes of hypopituitarism after pregnancy
- sheehan sydnrome
- lymphocytic hypophysitis
Lymphocytic hypophysitis presentation
- H/A
- visual disturbance
- hypopituitarism
Most accurate dating method
- first-trimester US w/crown rump length
Management of hypothyroidism during pregnancy
- Most women will require increased dose of levothyroxine, esp. during first trimester
- usually frequently check TSH, every 2-3 months
- usually elevated levels of total T3/T4 due to increased TBG
- important to manage hypothyroidism b/c can lead to defects in fetus
Early deceleration definition and etiology
- Early =
- symmetric w/contraction
- nadir of deceleration corresponds to peak of contraction
- gradual = >30s from onset to nadir
- Etiology
- fetal head compression
- can be normal
Late develeration definition and etiology
- Late
- delayed compared to contraction
- nadir occurs after peak of contraction
- gradual - >30s from onset to nadir
- etiology
- uteroplacental insufficiency
Variable deceleration definition and etiolgy
- Variable
- can be, but not necc., associated with contractions
- abrupt -
- decrease >15/min over >15s (but less than 2 min)
- etiology
- cord compression
- oligohydramnios
- cord prolapse
Differential diagnosis of vaginitis
- bacterial vaginosis = gardnerella vaginalis
- trichomoniasis = trichomonas vaginalis
- candida vaginitis = candida albicans
Bacterial vaginosis: exam findings, lab/wet mount findings, tx
- Exam
- thin, off-white discharge w/fishy odor
- no inflammation
- Lab
- pH>4.5 (basic)
- clue cells
- positive whiff test = amine odor w/KOH
- Tx = metronidazole (w/out partner tx)
Trichomoniasis: exam findings, lab/wet mount findings, tx
- Exam
- thin, yellow-green, malodorous, frothy discharge
- vaginal inflammation
- Lab
- pH > 4.5
- motile trichomonads
- Tx
- metronidazole + sexual partner tx
Candida vaginalis (yeast infection): exam findings, lab/wet mount findings, tx
- Exam
- thick, cottage cheese discharge
- vaginal inflammation
- Lab
- normal pH (3.8-4.2)
- pseudohyphae
- tx
- oral fluconazole
- intravaginal nystatin
Secondary amenorrhea definition
- absence of menses for >=3 cycles or >=6 months in women who menstruated previously
Evaluation of secondary amenorrhea
- Pregnancy test
- If negative + hx of prior uterine procedure or infection ==> hysteroscopy
- If negative w/out uterine procedure or infection hx ==> check prolactin, TSH, FSH
- Increased prolactin ==> brain MRI
- Increased TSH ==> hypothyroidism
- Increased FSH ==> premature ovarian failure
Baby born with microcephaly, hypoplasia of diastal phalanges of fingers/toes, excess hair, & cleft palate ==> dx?
- fetal hydantoin syndrome = small body size, microcephaly, dital hypoplasia, midface hypoplasia, hirsutism, cleft palate,, rib anomalies, developmental delay
- associated w/exposure to anticonvulsant medication during fetal development
- esp. phenytoin and carbamazepine
Presentation of congenital syphilis
- rhinitis
- hepatosplenomegaly
- skin lesions
- later findings…
- interstitial keratitis
- hutchunson teeth
- saddle nose
- saber shins
- deafness/CNS invovlement
Presentation of fetal alcohol syndrome
- midface hypoplasia
- microcephaly
- stunted growth
- CNS damage ==>
- hyperactivity
- cognitive disability
- learning disability
Dx and risks of PCOS
- PCOS
- suspected in any women with menstrual irregularity and clinical/biochemical signs of hyperandrogenism
- no need to see ovarian cysts to make dx
- unopposed estrogen ==> increased risk for endometrial carcinoma
Approach to management of endometriosis
- suspected endometriosis ==>
- if no contraindications or immediate need for dx ==> NSAIDs +/- combined hormonal contraceptives
- if no improvement ==> laparascopy
- if following conditions, proceed directly to laparoscopy ==>
- contraindications to medical therapy
- need for dx
- exclude malignancy or adnexal mass
- treat infertility
- urinary tract/bowel obstruction
Presentation/risks of endometriosis
- usually affects mulliparous women age 25-35
- ectopic endometrial tissue @: ovaries, ant/post cul-de-sac, broad ligaments, uterosacral ligmanets
- also @ fallopian tubes, sigmoid colon, appendix, round ligmanets
- often dysmenorrhea, dyspareunia, chronic pelvic pain that is worse before the onset of menses
- pelvic exam:
- rectovaginal tenderness
- tenderness w/movement of uterus
- can lead to infertility
Indications for prophylactic anti-D immune globulin administration (for unsensitized RH-neg pregnant patient)
- @ 28-32 weeks
- w/in 72hours of delivery of Rh-positive infant or spontaneous, threatened or induced abortion
- ectopic pregnancy
- hydatidiform molar pregnancy
- chorionic villus samping, amniocentesis
- abdominal trauma
- 2nd and 3rd trimester bleeding
- external cephalic version
Major types of vaginal cancer
- squamous cell carcinoma
- clear cell adenocarcinoma
Squamous cell vaginal cancer: epidemiology, risk factors, location, clinical features
- Age > 60
- Risk factors
- HPV 16/18
- Hx of cervial dysplasia/cancer
- cigarette use
- Location: upper 1/3 of posterior vaginal wall
- Clinical features
- malodorous vaginal discharge
- postmenopausal or postcoital vaginal bleeding
- irregular mass, plaque, ulcer on vagina
Clear cell adenocarcinoma: Epidemiology, Risk factors, location, clinical features
- Age
- Risk factors
- in utero exposure to diethylstilbestrol
- location: upper 1/3 of anterior vaginal wall
- clinical
- malodorous vaginal discharge
- postmenopausal or postcoital vaginal bleeding
- irregular mass, plaque, ucler on vagina
General presentation of uterine fibroids (leiomyoma)
- uterine leiomyoma = benign smooth muscle cell tumor of myometrium
- most common pelvic tumor found in women
- higher rates in African American women
- can cause extrinsic compression of bladder/colon ==> sx of urinary frequency or constipation
- can distort/enlarge uterus
- ==> heavy/prolonged menstrual bleeding
Raloxifene: MOA, use, contraindications
- MOA = mixed agonist/antagonist of estrogen receptors
- @ breast/vaginal tissue = antagonist
- @ bone = agonist
- use = first-line in prevention of osteoporosis
- decreases breast cancer risk
- risks/contraindications
- increased risk of thromboembolism
Definition and management of IUFD
- IUFD = death of fetus in utero occuring after 20 weeks and before onset of labor
- after dx of IUFD (lack of cardiac activity on US) ==> coagulation profile to check for DIC
- low-normal fibrinogen can indicate developing consumptive coagulopathy
- if coagulation derangement is suspected ==> immediate delivery
- if coagulation parameters are normal ==> expectant management vs. induction based on patient preference
Common liver disorders of pregnancy (3)
- intrahepatic cholestasis of pregnancy
- HELLP syndrome
- acute fatty liver of pregnancy
Intrahepatic cholestasis of pregnancy: presentation, lab abnormalities
- presentation: intense pruritis
- laboratory abnormalities
- elevated bile acids
- elevated liver aminotransferases
- ICP = dx of exclusion
HELLP syndrome: presentation, lab abnormalities
- presentation
- Pre-E
- RUQ pain
- N/V
- lab abnormalities
- hemolysis (elevated bili’s)
- moderate elevation in aminotransferases
- thrombocytopenia
Acute fatty liver of pregnancy: presentation, lab abnormalities
- presentation
- malaise
- RUQ pain
- N/V
- sequelae of liver failure
- lab abnormalities
- hypoglycemia
- mildly elevated liver aminotransferases
- elevated bilirubin
- possibly DIC
Presentation of pruritic urticarial papules and plaques of pregnancy (PUPPP)
- skin condition that develops during 3rd trimester
- red papules within striae with sparing of umbilicus
- sometimes extend to extremities
- palms, soles, face are rarely involved
- no lab or liver abnormalities
Initial step in management with decreased fetal movement
- non-stress tess
Criteria for reactive/nonreactive NST
- w/in 20 mins: at least 2 accelerations > 15bpm for at least 15s = reactive
- nonreactive if those are not met
- most common cause = fetal sleep cycle
- nonreactive ==> vibroacoustic stimulations to awake fetus and try again
Normal amniotic fluid index
between 5-25
Lecithin/sphingomyelin ratio meaning
- test that can be run on amniotic fluid and is an indicator of fetal lung maturity
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