Psychiatry

Question 1

Antipsychotics that cause QT prolongation

Answer 1

thioridazine
chlorpromazine
risperidone
zisapraside

Question 2

Antipsychotic known to cause myocarditis

Answer 2

Clozapine

Question 3

What are the antipsychotics that cause metabolic disorders; which disorders?

Answer 3

Atypical antipsychotics, especially olanzapine and clozapine. Cause diabetes, weight gain, and hyperlipidemia

Question 4

Which drugs are SSRIs

Answer 4

fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram, escitalopram

Question 5

SSRI SE

Answer 5

nausea, headaches, weight gain, delayed ejaculation/anorgasmia, neuromuscular restlessness, serotonin syndrome when combined with MAOi’s

Question 6

Which drugs are TCAs

Answer 6

Nortryptiline, imipramine, desipramine, clomipramine

Question 7

TCA SE

Answer 7

orthostatic hypotension, anticholinergic SE, sexual dysfunction, cardiac toxicity (tachycardia, SVTs, PQ/QRS/QT elongation, heartblock, ST/Twave changes

Question 8

Which Drugs are MAOi’s

Answer 8

selegiline, tranylcypromine, phenelzine, isocarboxazid

Question 9

MAOi’s SE

Answer 9

hyperadrenergic crisis with tyramine, serotonin syndrome with SSRIs, dose related orthostatic hypotension

Question 10

Signs of lithium toxicity

Answer 10

ataxia, diarrhea, coarse tremor, coma, death, sinus arrest

Question 11

What labs need to be monitored with lithium

Answer 11

TSH, creatinine, lithium serum levels

Question 12

Lithium side effects

Answer 12

hypothyroidism, polyuria (DIABETES INSIPIDUS) , tremor, GI distress, weight gain, acne

Question 13

Treatment for lithium induced diabetes insipidus

Answer 13

Amiloride + thiazide diuretics

Question 14

Valproate SE

Answer 14

teratogenic, liver failure, pancreatitis, thrombocytopenia, AGRANULOCYTOSIS

Question 15

Carbamazepine SE

Answer 15

agranulocytosis, pancytopenia, aplastic anemia, nausea and rash

Question 16

What is dissociative amnesia?

Answer 16

sudden retrograde autobiographical memory loss (usually personal info of a traumatic nature), not caused by any medical condition

Question 17

What are the low potency antipsychotics?

Answer 17

thioridazine, chlorpromazine

Question 18

What are the medium potency antipsychotics?

Answer 18

mesoridazine, perphenazine

Question 19

What are the high potency antipsychotics?

Answer 19

Haloperidol, Fluphenazine, trifluoperazine

molindrone, loxapine, thiothixane, pimozadine

Question 20

What are the atypical antipschotics?

Answer 20

apiprazole, clozapine, risperidone, olanzapine, paliperidone, quetiapine, ziprasidone

Question 21

What anticholinergic effects are caused by antipsychotics and which ones cause the most?

Answer 21

dry mouth, constipation, urinary retention, blurred vision

caused by low potency and med potency antipsychotics more than high potency antipsychotics

Question 22

Which antipsychotics lower seizure threshhold?

Answer 22

low potency –> thioridazine and chlorpromazine

clozapine

Question 23

Which antipsychotics cause hypotension?

Answer 23

Thioridazine and chlorpromazine

Risperidone

Question 24

Which antipsychotics cause agranulocytosis?

Answer 24

clozapine

Question 25

How do you monitor for clozapine induced agranulocytosis?

Answer 25

complete CBC:
once per week first 6 months
once/2weeks second 6 months
1x/month after a year

Question 26

Tourettes is associated with what other 2 conditions?

Answer 26

OCD ADHD