Psychiatry Flashcards
Trifluoperazine
1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic
Fluphenazine
1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic
Haloperidol
1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic
Chlorpromazine
1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic
Thioridazine
1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic
Olanzapine
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gain
4) Fun Facts:
Clozapine
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Clozapine specific: weight gain, agranulocytosis and seizures.
4) Fun Facts: Must monitor WBC. Must watch clozapine clozely
Ziprasidone
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Ziprasidone prolongs QT interval.
Quetiapine
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.
Risperadone
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.
Aripiprazole
1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette’s
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.
Lithium
1) Use: Bipolar, SIADH
2) Class/MOA: Not established. Related to phosphoinositol cascade (?)
3) Side effects/ADEs: Movement, Nephrogenic DI, hypOthyroidism, Pregnancy (LMNOP)
4) Fun Facts: May cause fetal cardiac defects, excreted by kidneys
Buspirone
1) Use: Generalized anziety disorder
2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines
Fluoxetine
1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect
Paroxetine
1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect