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Step 1 Pharm > Psychiatry > Flashcards

Psychiatry Flashcards

1
Q

Alcohol withdrawal

A

Benzodiazepines

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2
Q

Anxiety

(3)

A

SSRIs

SNRIs

Buspirone

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3
Q

ADHD

(2)

A

Methylphenidate

Amphetamines

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4
Q

Bipolar disorder

(2)

A

Mood stabilizers

(lithium, valproate, carbamazepine)

Atypical antipsychotics

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5
Q

Bulimia

A

SSRIs

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6
Q

Depression

(5)

A

SSRIs

SNRIs

TCAs

Buspirone

Mirtazepine

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7
Q

OCD

(2)

A

SSRIs

Clomipramine

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8
Q

Panic disorder

(3)

A

SSRIs

Venlafaxine

Benzodiazepines

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9
Q

PTSD

A

SSRIs

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10
Q

Schizophrenia

A

Antipsychotics

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11
Q

Social phobias

A

SSRIs

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12
Q

Tourette’s syndrome

A

Antipsychotics

(haloperidol, risperidone)

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13
Q

Increases catecholamines (DA, NE) at synaptic cleft

(3)

For ADHD, narcolepsy, appetite control

A

CNS stimulants

Methylphenidate

Dextroamphetamine

Methamphetamine

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14
Q

Block D2 receptors

(increase cAMP)

For schizophrenia, psychosis, acute mania, Tourette’s

Extrapyramidal signs, hyperprolactinemia, dry mouth, constipation, hypotension, sedation

Neuroleptic malignant syndrome, tardive dyskinesia

A

Typical antipsychotics

Haloperidol

-azines

(trifluoperazine, fluphenazine, thioridazine, chlorpromazine)

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15
Q

Rigidity, myoglobinuria, autonomic instability, hyperpyrexia

Treatment?

(2)

Think FEVER

A

Neuroleptic malignant syndrome

Dantrolene

D2 agonists (bromocriptine)

FEVER

Fever, encephalopathy, vitals unstable, elevated enzymes, rigidity of muscles

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16
Q

Stereotypic oral-facial movements

Long-term antipsychotic use

Treatment?

A

Tardive dyskinesia

Irreversible, no treatments.

17
Q

High potency antipsychotics

“Try to Fly High”

Neurologic side effect (extrapyramidal signs)

A

Trifluoperazine, fluphenazine, haloperidol

18
Q

Low potency antipsychotics

“Cheating Thieves are low”

Non-neurologic side effects

anticholinergic, antihistamine, alpha-1 blockade

Other side effects?

A

Chlorpromazine- corneal deposits

Thioridazine- retinal deposits

19
Q

Effects on 5-HT2, DA, alpha and H1 receptors

For schizophrenia, bipolar, OCD, anxiety disorder, depression, mania, Tourette’s

Few extrapyramidal, anticholinergic symptoms

Weight gain (2)

Agranulocytosis, seizure (1)

Long QT (1)

A

Atypical antipsychotics

Olanzapine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone

Weight gain- olanzapine, clozapine

Agranulocytosis, seizure- clozapine

Long QT- ziprasidone

20
Q

Unknown mechanism, possibly inhibition of

phosphoinositiol cascade

For bipolar (blocks relapse, acute mania), SIADH

Tremor, sedation, edema, heart block, hypothyroidism, polyuria, teratogenesis

Narrow therapeutic window

Reabsorption at PCT following Na+ reabsorption

A

Lithium

21
Q

Can cause fetal cardiac defects

Ebstein anomaly

Malformation of the great vessels

A

Lithium

22
Q

Stimulates 5-HT1A receptors

For generalized anxiety disorder

No sedation, addiction, tolerance, interactions with alcohol

A

Buspirone

23
Q

Serotonin-specific reuptake inhibitors

(4)

For depression, generalized anxiety disorder, panic disorder, OCD, bulimia, social phobias, PTSD

GI distress, sexual dysfunction, serotonin syndrome

Take 4 to 8 weeks for effect

A

SSRIs

Fluoxetine, paroxetine, sertraline, citalopram

24
Q

Hyperthermia, confusion, myoclonus, cardiovascular collapse, flushing, diarrhea, seizures

Treatment?

A

Serotonin syndrome

(from MAOIs, SNRIs, SSRIs, TCAs)

Tx: cyproheptadine

(5-HT2 receptor antagonist)

25
Q

Inhibit serotonin, NE reuptake (2)

For depression

For generalized anxiety disorder, panic disorder (1)

For diabetic peripheral neuropathy (1)

Raises BP, stimulant effects, sedation, nausea

A

SNRIs

Venlafaxine (anxiety, panic)

Duloxetine (neuropathy)

Duloxetine has greater effect on NEs

26
Q

Inhibits serotonin, NE reuptake

For major depression, bedwetting (1), OCD (1), fibromyalgia

Causes sedation, alpha-1 block (hypotension), cholinergic block (tachycardia, urinary retension, dry mouth), seizures, coma, arrhythmias, respiratory depression, fever, confusion, hallucinations.

How to treat cardiotoxicity?

A

TCAs

Amitriptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine

Anticholinergic: amitriptyline > nortriptyline

Desipramine less sedating, less seizure

Tx for cardiotox: NaHCO3

27
Q

Monoamine oxidase inhibition

Increases NE, serotonin, dopamine

For atypical depression, anxiety, hypochondriasis

Hypertensive crisis (tyramines), CNS stimulation

Contra: SSRIs, TCAs, St. John’s wort, meperidine, dextromethorphan

A

MAOIs

Tranylcypromine, phenelzine, isocarboxazid, selegiline

Selegiline selective for MAO-B

28
Q

Atypical antidepressant

Increases NE, dopamine

Used for smoking cessation

SE: stimulant, headache, seizure (bulimics)

No sexual side effects

A

Bupropion

29
Q

Atypical antidepressant

alpha-2 antagonist

Increases release of NE, serotonin

Potent 5-HT2, 5-HT3 antagonist

SE: sedation (good for depression + insomnia), increased appetite, weight gain (good for elderly, anorexics), dry mouth

A

Mirtazapine

30
Q

Atypical antidepressant

Blocks NE reuptake

SE: sedation, orthostatic hypotension

A

Maprotiline

31
Q

Atypical antidepressant

Inhibits serotonin reuptake

For insomnia

SE: sedation, nausea, priapism, postural hypotension

A

Trazodone

Step 1 Pharm (19 decks)

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