Psychiatry Flashcards

1
Q

Drugs for ADHD?

A
  1. Methylphenidate
  2. Atomexatine
    (and dexamfetamine)

SAME FOR YOUNG AND OLD

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2
Q

SSRIs

A

Citalopram
Fluoxetine
Sertraline
Paroxetine

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3
Q

Best SSRI for pt with chronic health problem

A

Sertraline
Less drug interactions
(and citalopram)

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4
Q

SSRI for < 18yrs?

A

Fluoxetine only

Careful monitoring to start

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5
Q

SNRIs?

A

Duloxetine

Venlafaxine

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6
Q

Diagnosis of ADHD?

A

Symptoms in at least 2 or more settings
At least moderate impairment on interviewing

DSM-IV criteria:
Inattentive symptoms - 6 or more
Hyperactivity-impulsivity symptoms - 6 or more

ICD-10 (Hyperkinetic disorder)
Inattentive symptoms - 6 or more
Hyperactivity - 3 or more
Impulsivity - 1 or more

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7
Q

First rank symptoms (Schneider)

A
Primary delusions
Delusions of control
Auditory hallucinations - 3rd person
Somatic hallucinations
Delusions of thought control
 - thought broadcasting
 - thought withdrawal
 - thought insertion
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8
Q

Weight gain most common in what antipsychotics?

A

Clozapine
Olanzapine
Phenothiazine

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9
Q

Typical antipsychotics MOA?

A

D2 antagonists

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10
Q

Typical antipsychotics examples?

A

Chlorpromazine
Prochlorperazine
Haloperidol
Flupentixol

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11
Q

Atypical antipsychotic examples?

A
Olanzapine
Clozapine
Risperidone
Aripiprazole
Quetiapine
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12
Q

Atypical antipsychotic MOA?

A

dopamine and 5HT2 antagonists

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13
Q

EPSE?

A

Extra-pyramidal side effects

More associated with TYPICALS rather than atypicals

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14
Q

Side effects of typical antipsychotics?

A

EPSE:

  • tardive dyskinesia (invol. movements of mouth/tongue)
  • Parkinsonism (cogwheel rigidity, bradykinesia etc)
  • Akathisia (subjective motor restlessness)
  • Acute dystonic reactions (oculogyric crisis and others)

Prolongued QT

Sedation

Hypotension

Neuroleptic malignant syndrome

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15
Q

Side effects of atypical antipyschotics?

A

Metabolic syndrome
Postural hypotension
Mild EPSE
Mild sedation

AGRANULOCYTOSIS especially clozapine

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16
Q

Which system in brain is being targeted for desired effects of antipsychotics?

A

Mesolimbic dopamine blockade

17
Q

Monitoring antipsychotic drugs?

A

Weight - weekly 6 weeks, then at 12 weeks, then annually
Waist circumference
Pulse, BP, blood sugar
ECG at start

Response to treatment and side effects

18
Q

Treatment resistant schizophrenia?

A

Prescribe clozapine if there has been no response to at least two sequential antipsychotics.

19
Q

First drugs for bipolar disorder: acute episode of mania?

A

Quetiapine
Risperidone
Haloperidol
Olanzapine

20
Q

Second line drugs for bipolar disorder acute episode of mania?

A

If first antipsychotic isn’t effective or tolerated, try another one. If not effective consider adding:
Lithium

Sodium valproate if lithium is not suitable

21
Q

Bipolar I and II?

A

Bipolar I = mania and depression

Bipolar II = hypomania and depression

22
Q

Hypomania and mania difference?

A

Presence of psychotic symptoms in mania, not in hypomania

23
Q

Monitoring Lithium?

A

Monitor serum lithium at days 4-7
Then weekly until stable (for 4 weeks)
Then every 3 months for 1st year
Then 6 monthly

24
Q

Lithium levels?

A
  1. 4-0.8 mmol/L if newly started on Li

0. 8-1 mmol/L if relapse whilst on Li

25
Q

First drugs for bipolar disorder acute depressive episode?

A

Quetiapine
Fluoxetine with olanzapine
Olanzapine
Lamotrigine

26
Q

What needs to be checked before starting Lithium?

A
Weight/BMI
FBC
TFT
U+E
Ca
eGFR
ECG
27
Q

Most superior antipsychotic?

A

Clozapine (atypical)

28
Q

Rapid tranquilization drug?

A

IM Lorazepam if unsure of patients history etc.

29
Q

MHA Section 2?

A
Assessment and treatment 
28 days
Section 12 approved doctor
GP of the patient
Approved Social worker (ASW)
30
Q

MHA Section 3?

A
Treatment
6 months
Section 12 approved doctor
GP of the patient
Approved Social worker (ASW)
31
Q

MHA Section 5.2?

A

Emergency
72 hours
Doctor only

32
Q

MHA Section 5.4?

A

Emergency
6 hours
Nurse

33
Q

MHA Section 4?

A

Emergency treatment
72 hours
Doctor
ASW

34
Q

MHA Section 136?

A

Emergency if someone is thought to have mental health disorder
Police may hold someone until assessment