Psychiatry Flashcards

1
Q

what diseases is cotard syndrome associated with? (2)

A

severe depression and psychotic disorders

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2
Q

SSRI of choice post myocardial infarction

A

sertraline

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3
Q

SSRI interactions

A

NSAIDs: NICE guidelines advise ‘do not normally offer SSRIs’, but if given co-prescribe a proton pump inhibitor
warfarin / heparin: NICE guidelines recommend avoiding SSRIs and considering mirtazapine
aspirin
triptans - increased risk of serotonin syndrome
monoamine oxidase inhibitors (MAOIs) - increased risk of serotonin syndrome

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4
Q

SSRI: when to review post starting?

A

Following the initiation of antidepressant therapy patients should normally be reviewed by a doctor after 2 weeks. For patients under the age of 25 years or at increased risk of suicide should be reviewed after 1 week. If a patient makes a good response to antidepressant therapy they should continue on treatment for at least 6 months after remission as this reduces the risk of relapse.

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5
Q

SSRI in pregnancy

A
  • Use during the first trimester gives a small increased risk of congenital heart defects
  • Use during the third trimester can result in persistent pulmonary hypertension of the newborn
  • Paroxetine has an increased risk of congenital malformations, particularly in the first trimester
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6
Q

Discontinuation symptoms SSRI

A

Gastrointestinal symptoms common. also:
- increased mood change
- restlessness
- difficulty sleeping
- unsteadiness
- sweating
- gastrointestinal symptoms: pain, cramping, diarrhoea, - vomiting
- paraesthesia

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7
Q

which ATYPICAL antipsychotic has a generally good side-effect profile, particularly for prolactin elevation

A

aripiprazole

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8
Q

Adverse effects of atypical antipsychotics

A

weight gain
hyperprolactinaemia
(stroke/ VTE risk)

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9
Q

Seasonal affective disorder management

A

you would begin with psychological therapies and follow up with the patient in 2 weeks to ensure that there has been no deterioration. Following this an SSRI can be given if needed.

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10
Q

clozapine side effects

A

agranulocytosis (1%), neutropaenia (3%)
reduced seizure threshold - can induce seizures in up to 3% of patients
constipation
myocarditis: a baseline ECG should be taken before starting treatment
hypersalivation

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11
Q

dose adjustment of cloazpine is needed if…

A

start or stop smoking

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12
Q

ECT side effects

A

Short-term side-effects
headache
nausea
short term memory impairment
memory loss of events prior to ECT
cardiac arrhythmia

Long-term side-effects
some patients report impaired memory

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13
Q

mirtazapine mechanism of action

A

alpha2-adrenergic receptorspeak incidence of seizures

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14
Q

peak incidence of seizures alcoholics

A

36hr

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15
Q

peak incidence delirium tremens

A

48-72 hours: coarse tremor, confusion, delusions, auditory and visual hallucinations, fever, tachycardia

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16
Q

when to admit people with ETOH

A

patients with a history of complex withdrawals from alcohol (i.e. delirium tremens, seizures, blackouts) should be admitted to hospital for monitoring until withdrawals stabilised

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17
Q

when to NOT give chlordiazepoxide for withdrawal of ETOH

A

liver cirrhosis –> Lorazepam

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18
Q

Anorexia features

A

most things low
G’s and C’s raised: growth hormone, glucose, salivary glands, cortisol, cholesterol, carotinaemia

19
Q

how long does section 136 last

A

24hr

20
Q

PHQ-9 score

A

PHQ-9 score <16 ‘less severe’ depression: encompasses what was previously termed subthreshold and mild depression

PHQ-9 score >16 ‘‘more severe’ depression: encompasses what was previously termed moderate and severe depression —> CBT and SSRI

21
Q

SSRI review - when to do 1 week

A

Patients ≤ 25 years who have been started on an SSRI should be reviewed after 1 week

22
Q

what type of medication is imipramine

A

strong anticholinergic effects due to their antagonism of muscarinic receptors. This anticholinergic activity leads to several characteristic side effects, with dry mouth (xerostomia) and blurred vision being amongst the most common. The blurred vision occurs due to paralysis of accommodation in the eye, whilst the dry mouth is due to reduced saliva production. These effects are predictable and commonly seen together in patients taking TCAs.

23
Q

Section 4

A

72 hour assessment order
used as an emergency, when a section 2 would involve an unacceptable delay
a GP and an AMHP or NR
often changed to a section 2 upon arrival at hospital

24
Q

GAD first line treatment

A

sertraline

25
Q

Light’s criteria state that a pleural effusion is an exudate if:

A

Effusion lactate dehydrogenase (LDH) level greater than 2/3 the upper limit of serum LDH
Pleural fluid LDH divided by serum LDH >0.6
Pleural fluid protein divided by serum protein >0.5

26
Q

small cell lung cancer management

A

chemotherapy

27
Q

chronic heart failure: what role does cardiac resynchronisation have

A

Cardiac resynchronisation therapy
for patients with heart failure and wide QRS
biventricular pacing
improved symptoms and reduced hospitalisation in NYHA class III patients

Exercise training
improves symptoms but not hospitalisation/mortality

28
Q

PERC score

A

rule OUT PE

this should be done when you think there is a low pre-test probability of PE, but want more reassurance that it isn’t the diagnosis

29
Q

WELLS PE score >4

A

CTPA

if 4 or less –> D dimer

30
Q

PE possible CXR finding

A

possible findings include a wedge-shaped opacification

31
Q

how does Mitral stenosis cause AF? (1)

A

secondary to left atrial enlargement

32
Q

common cause mitral stenosis

A

Rheumatic fever

33
Q

mitral stenosis: management

A

asymptomatic patients: monitored with regular echocardiograms
percutaneous/surgical management is generally not recommended

symptomatic patients:
percutaneous mitral balloon valvotomy
mitral valve surgery (commissurotomy, or valve replacement)

34
Q

mitral stenosis

A

viral infections (Coxsackie)
tuberculosis
uraemia
post-myocardial infarction
early (1-3 days): fibrinous pericarditis
late (weeks to months): autoimmune pericarditis (Dressler’s syndrome)
radiotherapy
connective tissue disease
systemic lupus erythematosus
rheumatoid arthritis
hypothyroidism
malignancy
lung cancer
breast cancer
trauma

35
Q

PCKD valvular problems

A

mitral valve prolapse and mitral regurgitation. . As many as 1 in 4 adults with polycystic kidney disease develop mitral valve prolapse.

36
Q

mitral valve prolapse

A

Associations
congenital heart disease: PDA, ASD
cardiomyopathy
Turner’s syndrome
Marfan’s syndrome, Fragile X
osteogenesis imperfecta
pseudoxanthoma elasticum
Wolff-Parkinson White syndrome
long-QT syndrome
Ehlers-Danlos Syndrome
polycystic kidney disease

37
Q

mitral valve prolapse features

A

patients may complain of atypical chest pain or palpitations
mid-systolic click (occurs later if patient squatting)
late systolic murmur (longer if patient standing)
complications: mitral regurgitation, arrhythmias (including long QT), emboli, sudden death

38
Q

Individuals with type 1 diabetes who do not have established cardiovascular disease (CVD) risk factors should be offered atorvastatin 20 mg for primary prevention of CVD if they are:

A

Older than 40 years of age
Have had diabetes for more than 10 years
Have established nephropathy
Have other CVD risk factors (such as obesity and hypertension)

39
Q

obstructer sleep apnoea: causees

A

obesity
macroglossia: acromegaly, hypothyroidism, amyloidosis
large tonsils
Marfan’s syndrome

40
Q

obstructer sleep apnoea:
diagnosis

A

sleep studies (polysomnography) - ranging from monitoring of pulse oximetry at night to full polysomnography where a wide variety of physiological factors are measured including EEG, respiratory airflow, thoraco-abdominal movement, snoring and pulse oximetry

41
Q

obstructer sleep apnoea:
management

A

weight loss
1st LINE= continuous positive airway pressure (CPAP) is first line for moderate or severe OSAHS
intra-oral devices (e.g. mandibular advancement) may be used if CPAP is not tolerated or for patients with mild OSAHS where there is no daytime sleepiness
the DVLA should be informed if OSAHS is causing excessive daytime sleepiness
limited evidence to support use of pharmacological agents

42
Q

drug causes of hyponatraemia

A

chlorpropramide, carbamazepine, selective serotonin reuptake inhibitor (SSRI) antidepressants, tricyclic antidepressants, lithium, MDMA/ecstasy, tramadol, haloperidol, vincristine, desmopressin, fluphenazine

43
Q

tests to odo before starting antipsychotics

A

Before starting antipsychotic medication, undertake and record the following baseline investigations: weight, waist circumference, pulse and BP, bloods (including fasting glucose, HbA1c, lipids and prolactin), assessment of movement disorders and nutritional status.

An ECG should also be offered if:
Specified in the summary of product characteristics (SPC)
Cardiovascular risk identified e.g. high BP
Personal history of cardiovascular disease
Service user is being admitted as an inpatient