Psychiatric Drugs

Question 1

SSRI’s
3 examples

Common SE (3 + 2 prolonged)
2 emergency

Answer 1

Sirtralline - (safest cardiac-wise)
Fluoxetine - watch out for Serotonin syndrome
Citalopram - QT prolongation

SE: Restlessness/agitation, GI disturbance, headache.

Sex dysfunction, weight change

Bleeding and suicidal thoughts.

Question 2

NSRI’s
2 examples

Common SE, which is more likely

Which drug not for heart disease

Answer 2

Venlafaxine - not for heart disease
Duloxetine

SE: Restlessness/agitation, GI disturbance, headache.

Sedation, nausea and sex dysfunction more likely.

Question 3

Special Categories

Mirt

Tricyclic

MAOI

New drug

Answer 3

Mirtazapine - weight gain and strong sedation

Tricyclic - amitriptylene, lofepramine, nortriptylene.
SE are antimusc and anti cholinergic.
Low dose neuropathic pain. Overdose prolongs QT interval prolong.

MAOI - Last resort drug for atypical depression, many interactions w/other drugs. Tyramine reaction (avoid meats, pickled, cheese and wine). Moclobamide

Vortioxetine. Many seritonergic agonist. Well tolerated.
Causes nausea.