Psychiatric Disordes

Question 1

What are Schizophrenia Symptoms?

Answer 1

3 Clusters: cognitive, deficit, psychotic
Dementia, hallucination, loosening of association

Question 2

How many people are affected by Schizophrenia?

Answer 2

0,25-0,75% of people. Male to female 3:2

Question 3

Risk factos of Schizophrenia?

Answer 3

Polygenetic with over 250 genes identified
Food deprivation in utero
DISC1 (Disrupted in schizo.) genetic abnormality, disrupts tail domain of protein-> disrupts anchoring of dynein at centrosome of cell

Question 4

Brain structure in Schizo?

Answer 4

Gray matter loss in prefrontal, parietal and temporal cortex
Decrease of connectivity, loss of spines

Question 5

Treatment of Schizo?

Answer 5

Cognitive Behavioral Therapy (CBT)
D2 receptor blockers

Question 6

Types of Depression?

Answer 6

Unipolar: Episodic, reocurring or chronic
Bipolar: alternating manic and depressive phases

Question 7

Prevalence of Depression?

Answer 7

5% of Population, Male to female 2:1

Question 8

Risk factors for Depression?

Answer 8

Highly Polygenetic
Poverty, Trauma, Social isolation, low education, Abuse, Neglect

Question 9

Brain Structure of Depression?

Answer 9

Amygdala less active, Reduced Neurogenesis in limbic system

Question 10

Depression Treatments?

Answer 10

CBT, Electroconvulsive therapy (Unknown why it works)
3 Classes of Drugs: MAO-B inhibitiors
Triclycic antidepressants: block noradrenalin transportsers
Selective serotonine uptake inhibitors