Psych Drugs

Question 0

tricyclics - drugs?

Answer 0

#Amitriptyline
#Nortriptyline
#Imipramine

Question 1

SSRIs - drugs?

Answer 1

Fluoxetine
Fluvoxamine
Paroxetine
Sertraline
Citalopram
Escitalopram

Question 2

Tricyclics - adverse affects?

Answer 2

#Dry mouth
#Arrhythmias, hypotension, confusion
#G.I. disturbances, constipation, weight gain
#Sexual side effects

Question 3

MAOIs - drugs?

Answer 3

#Phenelzine
#isocarboxazid
#tranylcypromine

Question 4

MAOI – Side effects?

Treatment?

Answer 4

Hypertension with food with tyramine (Red wine, aged cheese, chocolate)

Alpha blocker

Question 5

SSRI adverse effects?

Answer 5

#Blurry vision, hypertension (opposite of tricyclics)
#G.I. disturbances, weight changes
#Sexual side effects

Question 6

Bupropion – adverse effect?

Mirtazapine?

Answer 6

seizures

Weight gain and sedation

Question 7

Lithium – adverse effects?

Answer 7

#Nephrotoxic, diabetes insipidus
#Thyroid dysfunction 
#Weight gain, G.I. disturbances, tremors (same as Valproic acid)
#Teratogenic (Ebstein's)
#Leukocytosis

Question 8

Severe lithium toxicity result in?

Answer 8

#Confusion
#Ataxia
#Lethargy
#Abnormal reflexes

Question 9

Valproic acid – adverse effects?

Answer 9

#Hepatotoxicity
#Alopecia

#Tremors, weight gain, G.I. disturbances (same as lithium)
#teratogenic (same as lithium)

Question 10

Single Most effective treatment for depression?

Answer 10

ECT

Question 11

Symptoms of serotonin syndrome?

Answer 11

#Cognitive – agitation, confusion, hallucinations, hypomania
#Autonomic – sweating, hyperthermia, tachycardia, nausea/diarrhea, shivering
#Somatic – tremors, myoclonus

Question 12

Treatment of serotonin syndrome?

Answer 12

#stop SSRI and symptomatic treatment
#Cyproheptadine (serotonin antagonist)

Question 13

MAOI in pregnancy - do you stop it?

Answer 13

Yes

Question 14

Long QT in MAOI - treatment?

Answer 14

sodium bicarbonate

Question 15

SSRI discontinuation syndrome?

Answer 15

#dizziness
#paresthesias

Question 16

Psychiatric drug class that inhibits platelet aggregation?

Which specific drug is contraindicated in pregnancy?

Answer 16

SSRIs;

Paroxetine

Question 17

Weight gain bigger problem with which SSRI?

Answer 17

Paroxetine

Question 18

SSRIs that is most likely to have drug-drug interactions? Least likely?

Answer 18

Fluoxitene and paroxetine

Citalopram and escitalopram

Question 19

Bupropion - MoA?

Answer 19

Increase dopamine and NE

Question 20

Bupropion - indications? Contraindications?

Do not give to? Why?

Answer 20

SAD, depression, smoking cessation

Seizures

Anorexics, alcoholics, epileptics; seizures

Question 21

Side effects of bupropion?

Answer 21

Headache, weight loss, insomnia, ANXIETY, SEIZURES

Question 22

Venlafaxine- MoA?

Complications?

Answer 22

SNRI (SSRI at lower doses)

SSRI side effects - decreased libido, erectile dysfunction, headaches, insomnia, “weird, wired, funny” feeling,

NE side effects - hypertension, xerostomia

Question 23

Duloxetine - mechanism? Indications?

Do not take if?

Answer 23

Bicyclic SNRI;

Neuropathic pain, MDD, fibromyalgia, musculoskeletal pain, urinary incontinence

Liver disease

Question 24

Duloxetine vs Venlafaxine?

Answer 24

SNRI vs SNRI at higher doses

Same side effects but Duloxetine also has worse nausea, and liver damage

Question 25

Anxious, cachectic, depressed old lady - consider?

Answer 25

Mirtazapine - increased weight gain/appetite, will make drowsy

Question 26

Valproic acid - side effects?

Answer 26

GI disturbances&raquo_space;> neurologic, opthamalogic