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3a > Psych drugs > Flashcards

Psych drugs Flashcards

1
Q

What are the typical antipsychotics?

A
  • Haloperidol
  • Chlorpromazine
  • Flupentixol decanoate (depot)
  • Zuclopenthixol
  • Sulpride
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2
Q

What are the atypical antipsychotics?

A
  • Aripiprazole
  • Olanzapine
  • Quetiapine
  • Clozapine
  • Risperidone
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3
Q

Which antipsychotic drug is most likely to cause weight gain?

A

Olanzapine

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4
Q

What are the risks associated with clozapine?

A
  • Neutropenia and agranulocytosis
  • Constipation
  • Hyper-salivation
  • Tachycardia
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5
Q

What are the side effects of Lithium?

A

LITHIUM
- Leukocytosis
- Insipidus (diabetic)
- Tremors
- Hypothyroidism
- Increased urine
- Moms beware (teratogenic)

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6
Q

What’s the relationship between antipsychotics and dopamine?

A

Antipsychotics are dopamine antagonists

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7
Q

When can clozapine be offered?

A

When 2 or more treatments have been tried unsuccessfully

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8
Q

Typical or atypical antipsychotics:
More metabolic side effects?

A

Atypical

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9
Q

Typical or atypical antipsychotics:
Strong blockers of dopamine D2 receptors

A

Typical

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10
Q

Typical or atypical antipsychotics:
More motor side effects

A

Typical

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11
Q

Typical or atypical antipsychotics:
Greater risk of causing acute dystonic reaction

A

Typical

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12
Q

What type of side effects do you get with blocking the nigrostriatal pathway? Give some examples?

A

Extra-pyramidal side effects (movement side effects)
- Acute dystonia
- Parkinsonian symptoms
- Akathisia
- Tardive dyskinesia

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13
Q

What 4 pathways form the dopaminergic system

A
  • Mesolimbic tract
  • Mesocortical tract
  • Nigrostriatal tract
  • Tuberoinfundibular tract
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14
Q

What is a side effect of blocking the tuberoinfundibular pathway?

A

Hyperprolactinaemia

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15
Q

What is a side effect of blocking the mesolimbic pathway?

A

Reduced ability to feel pleasure

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16
Q

What is a side effect of blocking the mesocortical pathway?

A

Increasing the negative symptoms of psychosis

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17
Q

1) What is the role of benzodiazepines?
2) When are the indicated?

A

1) Sedative (reduce anxiety and improve sleep) and reduce the amount of antipsychotics needed
2) Severe anxiety, insomnia, psychotic illness

18
Q

Give 5 mood stabilisers

A
  1. Lithium
  2. Carbamazepine
  3. Valporate
  4. Lamotrigine
  5. Gabapentin
19
Q

Which drugs increase 5-HT

A

SSRIs

20
Q

What receptors do atypical antipsychotics work on?

A

D2, D3, D4, 5-HT

21
Q

What medication reduces alcohol craving?

A

Acamprosate

22
Q

What medication makes people feel sick when they drink alcohol?

A

Disulfiram

23
Q

What medication is used to manage the symptoms of alcohol withdrawal?

A

Chlordiazepoxide

24
Q

What do you need to monitor when starting or changing the dose of SNRIs?

A

BP - can cause HTN

25
Q

What do you need to get when starting citalopram? Why?

A

ECG - QT elongation

26
Q

What do you need to monitor when starting SSRIs?

A

U&Es - risk of hyponatraemia

27
Q

What antipsychotic increases the threshold for seizures?

A

Clozapine

28
Q

What antipsychotic dose may need adjusting with a change in smoking status?

A

Clozapine

29
Q

What drug is used for opioid detox?

A

Methadone

30
Q

What drug relieves opioid withdrawal?

A

Lofexidine

31
Q

What drug prevents opioid relapse?

A

Naltrexone

32
Q

What drug is treatment of opioid overdose?

A

Naloxone

33
Q

What drug reduces nicotine craving?

A

Varenicline

34
Q

What drug reduces pleasure from nicotine?

A

Bupropion

35
Q

Give 3 examples of dopamine agonists?

A
  • Ropinirole
  • Bromocriptine
  • Cabergoline
36
Q

Give 3 examples of MAOis?

A
  • Isocarboxazid
  • Phenelzine
  • Selegiline
37
Q

What antipsychotic fucks with blood glucose?

A

Olanzapine

38
Q

How does naltrexone decrease the pleasurable effect of alcohol?

A

Acts as an opioid antagonist

39
Q

How does acamprosate reduce alcohol craving?

A

Enhances GABA transmission

40
Q

How does disulfiram cause unpleasant symptoms on consumption of alcohol?

A

Causes acetaldehyde to build up

3a (34 decks)

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