Psych Drug Side Effects

Question 1

Lithium

Answer 1

“Lithium Mmm NOPe” M - Movement (tremor) N - Nephrogenic DI O - hypOthyroid P - Pregnancy (teratogen –> Ebstein anamoly)

Question 2

High Potency Neuroleptics

Answer 2

Extrapyramidal Side Effects -

• Acute dystonia –> akathisia –> Parkinsonism –> tardive dyskinesia

Neuroleptic Malignant Syndrome

• Fever, myoglobinuria, rigidity, autonomic instability
• Tx. w/ dantrolene & or bromocriptine

Question 3

Low Potency Neuroleptics

Answer 3

Anti-Cholinergic –> dry mouth, constipation, etc

Anti-Histaminergic –> sedation

Alpha₁ Blockade –> hypotension

Question 4

Atypical Antipsychotics

Answer 4

Weight gain

Question 5

Chlorpromazine vs. Thioridazone

(low potency neuroleptics)

Answer 5

Chlorpromazine = Corneal deposits

Thioridazone = retinal deposits

Question 6

Clozapine

Answer 6

Agranulocytosis*** & siezure

(weight gain)

Question 7

Ziprasidone

Answer 7

Prolonged QT

Question 8

Olanzapine

Answer 8

Significant weight gain –> diabetes

Question 9

SSRI

Answer 9

***Sexual Dysfunction

• anorgasmia & decreased libido

Can cause serotonin syndrome if combined w/ SNRI, TCA, or MAOi

Question 10

SNRI

Answer 10

Increase in BP initially

• may initially worsen anxiety

Question 11

TCA

Answer 11

Tri-C’s

• Convulsion
• Coma
• Cardiotoxicity (arrhythmias)

Anti-cholinergic effects (more w/ amitryptiline)

• Similar Sx’s as atropine OD

Alpha₁ Blocking –> postural like hypertension

Question 12

MAOi

(Trancypromine, Phenelzine, Isocarboxazin, Selegiline)

Answer 12

Hypertensive Crisis

• Must avoid ingestion of TYRAMINE

Question 13

Trazadone

Answer 13

Priapism

Sedation, nausea, postural HTN

*MOA = inhibit 5HT reuptake