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Step 1 > Immuno Drugs > Flashcards

Immuno Drugs Flashcards

1
Q

Cyclosporine MOA

A

Binds to cyclophilins –> Inhibits calcineurin - calcineurin normally activates IL2 transcription

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2
Q

Cyclosporine SE’s

A

Nephrotoxicity** - vasoconstriction of BOTH afferent & efferent hyperglycemia, HTN, gingival hyperplasia, hirsutisim

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3
Q

Tacrolimus (FK-506)

A

binds to FK-binding proteins –> inhibits calcineurin **similar outcomes & SE’s as cyclosporine

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4
Q

Sirolimus (rapamycin)

A

Inhibits mTOR - blocks Tcell proliferation in response to IL-2

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5
Q

Azathioprine

A

Antimetabolite precursor to 6-MP - blocks synthesis of nucleic acids - toxic to proliferating lymphocytes

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6
Q

Azathioprine SE’s

A

Bone marrow suppression *metabolized by Xanthine Oxidase

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7
Q

Muromunab (OKT3)

A

Binds CD3 & prevents T cell signal transduction

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8
Q

Mycophenolate

A

Inhibits IMP dehydrogenase –> prevents guanine synthesis ****Increases risk of lymphoma****

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9
Q

Thalidomide

A

Inhibits TNF alpha **used in leprosy

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Step 1 (6 decks)

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