Psych Flashcards
what disease has frequently smell hallucinations
Typical neurodegeneretive disorders like Parkinson, Alzheimers, epilepsy?
Bulimia vs Anorexia, similarities? (7)
- Both are eating disorders
- Both can include the binge-purge
- Both suffer from low self-esteem
- Bad self-image
- Both affected by genetic and enviornmental factors
- Hypotension (bulimia = tach, anorexia = brady)
- Malnutrition and low electrolytes
Bulimia vs Anorexia, main difference?
Bulimia = norm/overweight, Anorexia = underweight (BMI <18.5)
(Bulimia patients are more characterized by Binge-purge than anorexia patients=
DSM-V criteria for bulimia nervosa?
Binge-purge at least once/week over 3 months
Other signs that someone has bulimia? (6)
- Russel’s sign
- Mallory-Weiss syndrome
- Halatosis
- Eroded teeth
- Parotid gland swelling
- Loss of electrolytes and metabolic alkalosis (due to puking)
Treatment for bulimia? (2)
- Psychotherapy and CBT (try to eat small amounts of desired food, see that it has not consequenses)
- Medical: Fluoxetine
Typical signs of anorexia?
- BMI < 18,5
- Fear of Gaining Weight
- Bad self-image
- Binge-purge, overexercise
- Food rituals
- Refuse to eat in front of others
Physical changes with anorexia? (12)
- Muscle loss
- Hypotension with bradycardia (cardiac muscle loss)
- Orthostatic hypotnsion
- Edema (CHF and low protein)
- Electrolyte loss (decreased intake)
- B1 def
- Amenorrhea
- Bloating and constipation
- Pancytopenia
- Lanugo
- Osteoprorosis
- Refeeding syndrome!!
Treatment for anorexia? (2)
- CBT (individual and with family, improve self esteem etc…)
- Medical: Fluoxetine (if they take antipsychotics for something else, consider quetiapin or mirtazipin as they increase apetite)
Difference in ICD vs DSM? (9)
- ICD does not list characteristics/requirements to confirm diagnosis like DSM does
- ICD is more about clinical discression (guidelines rather than criteria)
- Especially different in the ways of classifying personality disorders (DSM classifies types, ICD clissify by severity and trait)
- DSM is better to diagnose people, as it doesn’t only list a bunch of symptoms where all need to be met, instead it tells you how many of the listed symptoms need to be met to determine a diagnosis
- DSM also allows clinical discression (remember, the DSM is just a manual, doesn’t need to diagnose even if criteria are met)
- ICD has less specified grouping on some disorders (example instead of choosing between bipolar or depressive disorder, you have a common goup in ICD called mood disorders)
- Different typing of schizophrenia
- Some disorders in ICD have their own chapter instead of being a part of “mental disorder” chapter (e.g sleep-wake disorders, as they often are due to neurological problems as well, not only psychiatric)
- DSM has exclusion criteria, while ICD puts these other possible disorders as their own part called “boundries with other disorders”
Diagnostic criteria for Schizophrenia? (5)
2 of the following symptoms with at least one being a major symptom lasting for at least 6 months were at least 1 month of that time is spent in active phase, and other causes must be ruled out:
- Delusions
- Hallucinations
- Disorganized speech (word-salad)
- Disorganized behaviour /catatonic behaviour (weard movements)
- Negative symptom
What are the 3 phases that Shizophrenia patients cycle through?
- Prodromal phase - withdrawn, anxiety
- Active phase - severe symptoms/positive symptoms
- Residual phase - cognitive symptoms (concentration problems)
Shizophrenia: Positive symptoms? (5)
- Delusions
- Hallucinations
- Disorganized speech
- Disorganized behaviour
- Catatonia
Shizophrenia, Negative symptoms? (3)
- Flat affect
- Alogia (poverty of speech)
- Avolition (decreased motivation)
Main treatment for Schizophrenia?
Atypical Antipsychotics!!! (Olanzapine, Quetiapine etc…)
*Supportive psychotherapy and training in social skills may also help
According to the old classification, what are the 5 subtypes of schitzophrenia?
- Paranoid: Where someone feels he is being persecuted or spied on.
- Disorganized: Where people appear confused and incoherent.
- Catatonic: Where people can be physically immobile or unable to speak.
- Undifferentiated schizophrenia: A subtype in which no paranoid, disorganized or catatonic features are prominent .
- Residual Schizophrenia: In which psychotic symptoms are markedly diminished or no longer present .
Which type of Schitzophrenia is treated with ECT?
Catatonic (though this is an old classification, these days ECT is reserved for treatment-resistant schizophrenia)
Another name for Disorganized Schizophrenia?
Hebephrenic Schizophrenia
Treatment depending on the subtype of Schizophrenia:
- Paranoid: AA
- Catatonic: ECT, AA + benzodiazepines (relax muscles –> easier movements, lorazepam can be used for both diagnosis and treatment)
- Undifferentiated: AA (respond slower, they are alert, but thinking takes time to recover if it does at all)
- Schizoaffective: AA + antidepressants/mood stabilisers
Etiology of Schizophrenia? (5)
Combination of physical, genetic, psychological and environmental factors:
- Identical twin of someone with the disease have a 50% chance of getting it themselves
- Shcizophrenia patients have small difference in brain structure
- Dopamine and Seretonin imbalance may be a cause
- Problems in birth may increase chance of developng it
- Stress and drug abuse may be a trigger of developing it in high-risk patients
Examples of type of delusions and hallucinations Schizophrenia patients might have?
- Delusions: of control (someone/something controls their actions) and reference (think insignificant remarks are directed at them “tv speaks to me”)
- Hallucinations: mainly auditory (hearing voices), but also some have visual hallucinations
What do we mean by “pillow sign” when discussing Schizophrenia?
Remember, these patients have abnormal movements! What we often see is that when these patients are lying down, their head might still stay elevated even though there’s no pillow under it (pillow sign).
Long term management of Schizophrenia?
Important that they get early medical treatment. Further on, psychotherapy for teaching them social skills and health managment so they can take care of themselves (remember to shower, get out of bed, be with others etc…)
Epidemiology of Schizophrenia?
- Prevelance: 1%
- Men = Women
- Earlier in Men (early 20’s, than in women (late 20’s)
- More in people with first-degree relatives
- Half of them attempt suicide
What do we mean by calling it “Autism Spectrum”
That it’s a spectrum of disorders differing in severity
2 major areas of consideration when evaluating Autism spectrum?
- Social communication and interaction
- Restricted or repetitive behaviour
These areas are again divided into sub-categories
4 subdivisons of Social communication and interactions in Autism?
- Social reciprocity - how child responds in social inteactions, autistic children often want to be alone
- Joint attention - ability to share interest with someone else
- Nonverbal communication - using or interpreting nonverbal communication (e.g child doesn’t put its arms up when it wants to be picked up, or can’t tell when parents are upset from their body language)
- Social relationships - making and maintaining friends (behaviour problems)
Restricted or repetitive behaviour in autism? (6)
- Lining up toys
- flapping hands
- imitating words or phrases
- fixated routines
- restrictive thinking (fixated on knowing about one major subject like vacuum cleaners)
- Hypo- or hyperactivity to sensory input
Other important signs commonly seen in autism? (2)
- reacts badly to sounds
- problems maintaining eye contact
Important cooperative partner in diagnosing autism?
Parents or teachers, as many of the symptoms can be observed at home or in school, parents can be given a list of things to look for or a severity chart
How does a severity chart in autism organised?
As a spectrum from level 1 (high-functioning) to level 3 (severe autism)
Give an example of how autism lvl 1 can manifest?
- Patient can maybe speak full sentences, but have problem with having a conversation with others (back and forth exchange of info)
- May show some difficulty with exchanging between activities
Give an example of a lvl 3 autism
- only speak a few words or rarely interacts
- extremely resistant to change
- problems are considered to severely interfere with daily life
In addition to the signs, what other criteria has to be met before an autism diagnosis can be set? (3)
- Has to interfere with daily life (social, academic etc…)
- Has to manifest itself from an early age (< 3 years old)
- Exclude disorders with similar symptoms
Asperger syndrome, where does it fall on the autism spectrum?
level 1
Exclusion disorders similar to autism? (4)
- Rett syndrome (genetic disorder, slow development in early age)
- Hearing impairment (rule out with audiometry)
- Selective mutism (refusal to speak)
- Intellectual disability
Diagnostic criteria for autism?
- Patient must experience all communicating problems, and at least 2 restricted/repetitive behaviour symptoms
- Must be < 3 years old
- Must be considered an issue to daily life
- Other causes are excluded
Etiology of autism?
Mainly thought to be due to genetic causing changes in brain development (though no genes have been specified yet)
Treatment for autism?
- Special education
- Lifelong behavioural management
- Symptom-targeted medication
- Neuroleptics for aggression
- SSRI for repetitive behaviour
Symptoms of mania? (DIG FAST)
- Distractability
- Insomnia
- Grandiosity (high self-esteem)
- Flight of ideas
- Activities (psychomotor Activation)
- Sexual indiscretions (or other pleasurable activities)
- Talkativeness/pressured speech
Difference between mania and hypomania? (4)
- Mania is more severe
- Mania > week || Hypomania >4 days
- Mania causes significant problems in social/occupational function, while Hypomania doesn’t
- Mania may be have psychotic features, Hypomania doesn’t
Shortly explained, what is Bipolar disorder?
A disorder where a patient shifts between periods of extreme lows (depression similar to Major depressive disorder) and extreme highs (mania)
3 types of Bipolar Disorder?
- Bipolar 1
- Bipolar 2
- Cyclothemia
Manic-depressive interval of bipolar disorder 1?
- Depressive episodes lasting > 2 weeks
- Manic episodes lasting > 1 week (though can last for months)
Manic-depressive interval of bipolar disorder 2?
- Depressive episodes lasting > 2 weeks (like in bipolar 1)
- HYPOmanic episodes lasting > 4 days
Manic-depressive interval of Cyclothymia?
- Less severe depressive episodes
- Less severe manic episodes
Depressive and manic episodes are similar in duration here
2 variations that may occur within the cycle of bipolar disorder?
- Mixed episodes - where depression and mania may occur at the same time
- Rapid cycling - 4 or more episodes of depression or mania within 1 year
Etiology of Bipolar disorder?
Genetic and enviromental
- 10x risk if family member has it
- High risk if you have other psych-disorder
General treatment for Bipolar disorder?
- Lifelong moodstabilizers (first line, and can be used alone i monotherapy)
- Consider including or replacing with antipsychotics if mood stabilizers can’t control mania
- Consider including SSRI if mood stabilizers can’t control depression
- ECT if mania is refractory
Which mood stabilizers may be used in bipolar disorder?
- Lithium (first line)
- Lamotrigine (second line)
- Carbamezipine
- Valproic Acid
Which mood stabilizer is NOT teratogenic?
Lamotrigine
Lithium side effects? (9)
- GI symptoms (nausea/diourrhea…)
- Milde tremors
- Polyuria/Nefrogenic Diabetes Insipidus (blocks ADH-rec)
- Acute kidney failure
- Hypothyroidism (blocks TSH-receptors) and Goiter
- Leukocytosis
- Teratogenic (Epstein’s anomaly in fetus)
- Neurologic symptoms (ataksia, dysarrthria, confusion, coma)
- Skin (psoriasis, dermatitis, acne)
Therapeutic index of lithium?
0.6 - 1.5 mmol/L
Why do most bipolar patients need Lithium + SSRI treatment?
Cause mood stabilizers like lithium are best at controlling manic episodes than they are at controlling depressive episodes
Treatment for acute mania (severe) in bipolar patients? example?
- Mood stabilizer + Antipsychotic
- Lithium + Haloperidol is a common combo, but atypical antipsychotics like Olanzapine and Quetiapine may also be used
Typical or atypical antipsychotics for mild/moderate mania?
Atypical er usually used (although typical are also effective)
Treatment for bipolar pregnant patient
CAVE: Mood stabilizers (Lithium and Valproic acid are bad for fetus)
- Give typical antipsychotics like Haloperidol for mania
- Give SSRI like escitalopram for depression
Treatment option if you want to switch mood-stabilizer monotherapy with something else when treating bipolar patients?
- Atypical antipsychotic (Aripiprazole, Olanzapine, Quetiapine…) for mania
- SSRI for depression
Why do you have to be careful when treating bipolar patient with SSRI?
Cause it might increase the mania!
Other possible medications that may be used in bipolar disorder? (2)
- Anticonvulsants (Lamotrigine, Valpric Acid, Carbamezipine)
- Benzodiazepines
What’s a delusion and how can it manifest itself as? (8)
Delusion is a break from reality, with fixed false beliefs that can’t be changed with reasonable arguments
- Paranoia
- Ideas of reference
- Thought broadcasting
- Delusions of grandur
- Delusions of guilt
- Persecutory delusions
- Erotomanic delusions
- Somatic delusions
What’s paranoia?
feeling being followed, tracked or targeted
What do we mean by “Ideas of reference”?
Believe some event is especially related to them (“the guy on tv is talking to me”)
What’s Thought broadcasting?
To believe others can hear their thoughts
What are Delusions of Grandur?
Believe they have special powers or are sent on a special misson that only they can do
What are Delusions of guilt?
To believe unrelated events are somehow their fault (“WW2 is my fault”)
What are Persucatory delusions?
Believing they are being harassed by others, even though they’re not
What are Erotomanic delusions?
Feeling someone that doesn’t know them are in love with them (being in love with an movie star)
What are Somatic delusions?
Thinking you have a somatic ilness even though you don’t
What types of hallucinations are there? (5)
- Visual hallucination (seeing)
- Olfactory (phantosmia).
- Gustatory hallucinations (tatse)
- Auditory hallucinations (hearing)
- Tactile hallucinations /feeling)
Most common cause of visual hallucinations?
Lewy body dementia or drug intoxication
Most common cause of olfactory hallucinations?
Neurodegenerative disorders like parkinson and alzeihmers, but also Epilepsy with aura (affecting temporal region)
Most common cause of tactile hallucinations?
Drug or alcohol abuse
What’s the difference between obsessions and compulsions?
- Obsessions: recurrent, intrusive thoughts that may cause anxiety
- Compulsions: actions that OCD patients do to reduce the anxiety that comes from the obsessions (impact daily life)
Give examples of obsessions and their compulsions
- Germs –> Cleaning
- Unsafe –> Checking
- “Something bad wil happen” –> Repeating
- Anxiety –> Arranging
- Bad thoughts –> come up with words or phrases to replace the bad thoughts and turn them into good thoughts (mental rituals)
DSM criteria for OCD? (4)
Following criteria has to be met:
- Having obsessions, compulsions or both
- Time consuming (distress in daily life)
- Not due to substance abuse or somatic illness
- Rule out other mental disorder (OCPD etc…)
Causes for OCD?
- Genetics (higher risk if you have an identical twin with OCD)
- Environment and upbringing
- Seretonin abnormalities
Treatment for OCD? (5)
- CBT (Exposure and response therapy), where patient is exposed for trigger of obsession, but learns to handle anxiety without doing compulsion
- Medication: SSRI (sertraline or escitalopram), Antipsychotics (Risperidone), TCA (clomipramine)
- Deep brain stimulation (brain pacemaker) for refractory OCD
- Neuromodulory surgeries as last resort for severe refractory OCD
First line and second line treatment regimen for OCD?
- First-line: CBT + SSRI (sertarlin)
- SNRI (venlafaxine) + TCA (Clomipramine)
1st-line treatment for trichotillomania?
TCA (Clomipramine)
SSRI dosage when treating OCD?
- Sertraline, start 25mg, increase to 50mg afte 1 week (if you need to increase further, you can increase by 50mg at a time each week, up to a max dosage 200mg/day
- Escitalopram, start 10mg, can increase dosage up to 20mg
How does SSRI treatment of OCD differ from SSRI treatment in depression?
OCD may require higher SSRI dosage and longer time for treatment to have effect
Explain the Psychodynamic theory on OCD?
Psychodynamic theories of OCD state that obsessions and compulsions are signs of unconscious conflict that you might be trying to suppress, resolve, or cope with.11 These conflicts arise when an unconscious wish (usually related to a sexual or aggressive urge) is at odds with socially acceptable behavior.
What is Agoraphobia?
A fear of leaving the house
How to treat Agoraphobia?
- 1st line: CBT + SSRI (sertralin)
- Benzodiazepines or pregabalin may also be of help as they have a relaxing effect
Common rule to remember when giving a personality disorder diagnosis?
Make sure the patient is over 18 years old!! (because it’s normal for teenager to behave oddly cause they’re premature and hormonal, and it usually goes over for them)
Subdivisions of Cluster A personality disorders? (3)
“Weird”
- Paranoid personality disorder (accusatory)
- Schizoid personality disorder (alone)
- Schizotypal personality disorder (awkward)
How does Paranoid personality disorder manifest itself? (7)
- Accusatory
- Distrustful and suspicious of others
- Assume that others will dissapoint, manipulate or talk shit about them (have superficial relationships, often live in isolation)
- They try to ensure loyalty of friends and family
- Act severely if they feel like they’ve been lied to or backstabbed
- Hold grudges for long of time
- In return their behaviour often leads to people starting to dislike them or talk badly about them