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Parker Derm Pharm > Psoriasis/Acne > Flashcards

Psoriasis/Acne Flashcards

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Dermatology Board Prep flashcards
1
Q

What are the TNF-alpha antibodies that treat psoriasis?

A

Adalimumab, Etanercept, Infliximab

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2
Q

Infliximab ADE

A
  1. Heart failure

2. Murine protein hypersensitivity

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3
Q

Etanercept ADE

A

Sepsis

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4
Q

BBW for all TNF-alpha antibodies?

A

Infection, neoplasia, TB

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5
Q

Ustekinumab MOA

A

binds p40 subunit integral to IL-12 & IL-23 (over-expressed in psoriasis) –> suppression of Th1 & Th17 cells

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6
Q

Ustekinumab ADE

A

Increased risk of infection & neoplasia; live virus vaccinations are contraindicated. Test for TB before initiating infection

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7
Q

Which retinoids target retinoic acid receptors (RARs)?

A

Tretinoin, Adapalene, Tazarotene

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8
Q

Acute ADEs of retinoids

A

Dry skin, epistaxis, conjunctivitis, reduced night vision, alopecia

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9
Q

Before starting therapy with retinoids, what must you do?

A

Baseline serum lipid, serum transaminases, CBC and pregnancy test (RETINOIDS ARE TERATOGENS!!)

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10
Q

Isoretinoin (accutane) serious ADE?

A

Depression, suicidal ideation

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11
Q

Calcipotriene MOA

A

Vitamin D analog –> treats psoriasis

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12
Q

Calcipotriene ADE

A
  1. Topical irritation
  2. Hypercalcemia
  3. Increased susceptibility to UV induced skin cancer
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13
Q

Calcitriol MOA

A

Hormonally active form of Vitamin D

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14
Q

Calcitriol difference from Calcipotriene?

A

Better tolerated

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15
Q

Benzoyl peroxide MOA

A

Prodrug –> converted to benzoic acid –> free radical liberation lethal for nearby P. acnes

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16
Q

Benzoyl peroxide ADE

A

Contact dermatitis, pruritis, blistering, crusting.. Basically any form of skin irritation

17
Q

What is the mild corticosteroid that can treat psoriasis/acne?

A

Hydrocortisone

18
Q

What is the moderate corticosteroid?

A

Beclomethosone dipropionate

19
Q

What is the very potent corticosteroid

A

Clobetasol propionate

20
Q

RAR selective retinoids ADE’s?

A

Mucocutaneous & musculoskeletal symptoms

21
Q

Isotretinoin effects?

A

Decreased sebum secretion and sebaceous gland size

22
Q

Retinoids effects?

A
  1. Modulation of proliferation & differentiation
  2. Inhibition of keratinization
  3. Alterations of cellular cohesiveness
  4. Decreased sebum secretion & sebaceous gland size (isotretinoin)
  5. Immunologic and anti-inflammatory effects
  6. Tumor prevention and therapy
  7. Induction of apoptosis
  8. Effect on extracellular matrix components
23
Q

Isotretinoin mild ADE?

A

Photosensitivity.. All retinoids you must be concerned about UV sensitivity!!

Parker Derm Pharm (8 decks)

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