"Old" Cancer drugs

Question 1

What class is Cyclophosphamide in? Is it a prodrug?

Answer 1

Cyclophosphomide is a nitrogen mustard and is a prodrug

Question 2

Cyclophosphomide MOA

Answer 2

Binds N7 of guanine and alkylates DNA producing intra or inter strand cross links that prevent DNA replication

Question 3

Cyclophosmphamide ADE

Answer 3

Hemorrhagic cystitis

Question 4

Cyclophosphamide adjuvant therapy?

Answer 4

Mesna

Question 5

Platinum drug?

Answer 5

Cisplatin

Question 6

Cisplatin MOA

Answer 6

Binds N7 of guanine and causes mostly intra strand crosslinks

Question 7

Cisplatin ADE

Answer 7

Renal & Oto toxicity

Question 8

Adjuvant therapy of Cisplatin?

Answer 8

Amifostine

Question 9

Nitrosoureas?

Answer 9

Carmustine, Lomustine

Question 10

MOA of Carmustine

Answer 10

Alkylation and carbamoylation of amino acids

Question 11

ADE of Carmustine

Answer 11

1. CNS (seizures)

2. Hepatic veno-occlusive disease

Question 12

Adjuvant therapy of nitrosoureas

Answer 12

Defibrotide

Question 13

Cyclophosphamide treats?

Answer 13

BCC

Question 14

Cisplatin treats?

Answer 14

BCC, SCC

Question 15

Carmustine, Lomustine treat?

Answer 15

Melanoma

Question 16

Dacarbozine MOA

Answer 16

Methylates O6 guanine