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Parker Derm Pharm > Leprosy Drugs > Flashcards

Leprosy Drugs Flashcards

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Dermatology Board Prep flashcards
1
Q

Dapsone MOA

A

Folate antagonist- competes with para-aminobenzoate for the active site of dihydropteroate synthesis

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2
Q

Dapsone is administered with what other drugs in treatment of leprosy?

A

Rifampicin & Clofazimine

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3
Q

Dapsone ADE

A

Dapsone syndrome: hemolysis, methoglobinemia, hepatitis, jaundice, peripheral neuropathy, hypoalbuminemia, psychosis, leukopenia

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4
Q

Other Dapsone ADE

A

Rash on upper limbs and forehead

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5
Q

Yet another Dapsone ADE

A

Dermatitis, lymphadenopathy (along posterior border of STM muscle), and Stevens-Johnson syndrome

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6
Q

Rifampin MOA

A

Inhibits bacterial DNA dependent RNA polymerase

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7
Q

Rifampin ADE

A

Big one is body fluid discoloration! Also hepatotoxicity, hemolysis, hemoglobinuria, renal failure, and flue like symptoms

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8
Q

Rifampin is a CYP inducer or inhibitor?

A

Inducer –> multiple drug interactions

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9
Q

Rifampin metabolism?

A

Enterohepatic circulation

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10
Q

Distribution of Rifampin

A

Everywhere! Crosses placenta, gets in breast milks, crosses BBB!

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11
Q

Clofazimine MOA

A

Binds to mycobacterial guanine in DNA.. Frequency of mycobacterial guanine & cystine&raquo_space;> in human DNA

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12
Q

Clofazimine ADE

A
  1. Staining of body, body fluids, & suckling infant!
  2. Feces can appear dark/tarry (would look like GI bleed)
  3. Possible hepatitis & jaundice
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13
Q

Why does Clofazimine have such long persistence?

A

It is very lipophilic

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14
Q

What adverse drug reaction of leprosy treatment does Clofazimine treat?

A

Erythema nodosum leprosum (will discuss this more later)

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15
Q

What do corticosteroids do for lepors?

A

Treat type 1 and type 2 adverse drug reactions from leprosy therapy

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16
Q

Describe a type 1 adverse reaction

A

Red patchy skin lesions, erythema, swollen hands/feet, joint pain

17
Q

What is the treatment for a type 1 adverse reaction to leprosy therapy?

A

Corticosteroids

18
Q

Describe a type 2 adverse reaction

A

It is aka erythema nodosum leprosum- sudden eruption of numerous painful nodules; neuritis

19
Q

How do you treat a type 2 adverse reaction to leprosy therapy

A

Corticosteroids, Clofazimine, Thalidomide

20
Q

Thalidomide MOA

A

Inhibits NFkB (transcription regulation) and TNF-alpha (leukocyte migration)

21
Q

Thalidomide ADE

A

Teratogen, Increase in plasma HIV viral load (know this!!), rarely peripheral neuropathy

Parker Derm Pharm (8 decks)

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