Hyperhydrosis Flashcards
How many eccrine sweat glands do you have? How many apocrine?
3 million eccrine; 1 million apocrine
Where are your eccrine sweat glands
Everywhere! Sole of feet > forehead > palm > cheek
Where are your apocrine sweat glands
Armpits & anogenital area
Why does axillary and anogential sweat smell bad?
Secretes thick fluid that is degraded by bacteria into odiferous products
Innervation of eccrine sweat glands is via what neurotransmitter?
Acetylcholine
Innervation of apocrine sweat glands is via what neurotransmitter?
Catecholamine
Botulinum toxin is from what bacteria
Clostridium botulinum
Botox MOA
Cleaves SNARE proteins that allow for binding of ACh vesicle to cell membrane
How does Botox get into cells?
Heavy chain binds to an unidentified receptor and it is endocytosed
How does your body eventually “overcome” the botox
Sprouting: new nerve terminal sprout up and bypass the botox that has affected the previous nerve endings
Application of botox?
Injection
List the anticholinergic that is used off label to treat hyperhydrosis
Glycopyrrolate
Botox ADE
- Muscular paralysis
- Systemic botulism is rare but reported –> respiratory event –> death
- Anticholinergic effects: dry mouth, pain at injection site, tiredness, headache, neck pain, eye probs
- Product contains albumin –> allergy
Botox blocks what 2 receptors
Nicotinic & Muscarinic
What calcium channel blocker is used to treat hyperhydrosis?
Diltiazem
