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Parker Derm Pharm > Miscellaneous Dermal Drugs > Flashcards

Miscellaneous Dermal Drugs Flashcards

1
Q

What is Minoxidil?

A

Rogaine

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2
Q

Minoxidil MOA

A

Unknown.. maybe activates hair follicles; maybe alters androgen metabolism

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3
Q

ADE of Minoxidil are unlikely; however, what conditions may increase the percutaneous absorption and lead to adverse effects?

A

Skin abrasions like psoriasis or sunburn

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4
Q

What must you express to your patient about use of Minoxidil and its effectiveness?

A

Minoxidil must be continually used to be effective

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5
Q

Administration of Minoxidil?

A

Topical

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6
Q

Finasteride administration?

A

Oral

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7
Q

Finasteride treats?

A

Hair loss, BPH

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8
Q

Dosage for hair loss? Dosage for BPH?

A

Hair loss: 1mg daily

BPH: 5mg daily

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9
Q

Finasteride MOA

A

Testosterone analog: blocks 5-alpha-reductase activity –> decreased scalp and serum DTH concentrations

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10
Q

Finasteride ADE

A

New research shows it may decrease libido and lead to sexual dysfunction

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11
Q

What OTC natural remedy for BPH interferes with Finasteride?

A

Saw Palmetto increases Finasteride’s activity

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12
Q

Eflornithine’s clinical use?

A

Removes unwanted female hair (facial hirsutism)

Also treats African Sleeping Sickness

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13
Q

Eflornithine administration?

A

Topical

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14
Q

Eflornithine MOA

A

Decreases ornithine decarboxylase

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15
Q

Eflornithine ADE

A

“Skin adverse events are rare and mild” Do not apply around eyes or mucus membranes

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16
Q

Is Eflornithine a dipilatory agent?

17
Q

Methoxsalen clinical use

A

Treats Vitiligo, Psoriasis, T-cell lymphoma, alopecia areata, inflammatory dermatosis, eczema, lichen planus

18
Q

Administration of Methoxsalen

A

Oral or topical

19
Q

Describe the unique MOA of Methoxsalen

A

It is activated by UVA. So you give the patient Methoxsalen then expose them to UVA light (320-400nm). The desired effect is to kill the “bad cells”

20
Q

Chemotherapy induced alopecia depends on?

A

Drug, dose, intensity, route of administration

21
Q

How long does it take for chemo to induce complete alopecia?

A

2-3 months

22
Q

Describe “scalp cooling”

A

Chemo pts wear a cold hat to vasoconstrict the blood vessels under their scalp in the hopes that not as much chemo will get there and they will not lose their hair.

23
Q

What is an adverse concern about scalp cooling?

A

If you vasoconstrict the scalp vessels, they could get a sub-lethal dose of chemo thus the cancer could survive in the scalp.. It is contraindicated in hematologic malignancies

24
Q

Methoxsalen treats?

A

Hyperpigmentation.. it stops melanin

Parker Derm Pharm (8 decks)

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