Miscellaneous Dermal Drugs

Question 1

What is Minoxidil?

Answer 1

Rogaine

Question 2

Minoxidil MOA

Answer 2

Unknown.. maybe activates hair follicles; maybe alters androgen metabolism

Question 3

ADE of Minoxidil are unlikely; however, what conditions may increase the percutaneous absorption and lead to adverse effects?

Answer 3

Skin abrasions like psoriasis or sunburn

Question 4

What must you express to your patient about use of Minoxidil and its effectiveness?

Answer 4

Minoxidil must be continually used to be effective

Question 5

Administration of Minoxidil?

Answer 5

Topical

Question 6

Finasteride administration?

Answer 6

Oral

Question 7

Finasteride treats?

Answer 7

Hair loss, BPH

Question 8

Dosage for hair loss? Dosage for BPH?

Answer 8

Hair loss: 1mg daily

BPH: 5mg daily

Question 9

Finasteride MOA

Answer 9

Testosterone analog: blocks 5-alpha-reductase activity –> decreased scalp and serum DTH concentrations

Question 10

Finasteride ADE

Answer 10

New research shows it may decrease libido and lead to sexual dysfunction

Question 11

What OTC natural remedy for BPH interferes with Finasteride?

Answer 11

Saw Palmetto increases Finasteride’s activity

Question 12

Eflornithine’s clinical use?

Answer 12

Removes unwanted female hair (facial hirsutism)

Also treats African Sleeping Sickness

Question 13

Eflornithine administration?

Answer 13

Topical

Question 14

Eflornithine MOA

Answer 14

Decreases ornithine decarboxylase

Question 15

Eflornithine ADE

Answer 15

“Skin adverse events are rare and mild” Do not apply around eyes or mucus membranes

Question 16

Is Eflornithine a dipilatory agent?

Answer 16

No

Question 17

Methoxsalen clinical use

Answer 17

Treats Vitiligo, Psoriasis, T-cell lymphoma, alopecia areata, inflammatory dermatosis, eczema, lichen planus

Question 18

Administration of Methoxsalen

Answer 18

Oral or topical

Question 19

Describe the unique MOA of Methoxsalen

Answer 19

It is activated by UVA. So you give the patient Methoxsalen then expose them to UVA light (320-400nm). The desired effect is to kill the “bad cells”

Question 20

Chemotherapy induced alopecia depends on?

Answer 20

Drug, dose, intensity, route of administration

Question 21

How long does it take for chemo to induce complete alopecia?

Answer 21

2-3 months

Question 22

Describe “scalp cooling”

Answer 22

Chemo pts wear a cold hat to vasoconstrict the blood vessels under their scalp in the hopes that not as much chemo will get there and they will not lose their hair.

Question 23

What is an adverse concern about scalp cooling?

Answer 23

If you vasoconstrict the scalp vessels, they could get a sub-lethal dose of chemo thus the cancer could survive in the scalp.. It is contraindicated in hematologic malignancies

Question 24

Methoxsalen treats?

Answer 24

Hyperpigmentation.. it stops melanin