Psoriasis Flashcards
What is psoriasis?
Chronic immune mediated disease
What is the pathophysiology of psoriasis?
Increased production of skin cells via autoimmune reaction
Cell cycle reduced from 28 to 5 days, –> build up of skin
What are the types of psoriasis?
1= familial, common, early onset 2= related to other autoimmune conditions and environment, older onset
What is the histology of psoriasis?
Hyperkeratosis
Dilated dermal capillaries
Neutrophils and T cell infiltration
What are the features of psoriasis?
Sharply demarcated, circumscribed erythematous plaques- scaly white superficial layer
Erythematous
Often symmetric
Where does psoriasis affect?
Extensor surfaces- elbows, knees
Scalp
Nail changes
What are the types of psoriasis? 7
Chronic plaque Guttate Palmo-plantar Scalp Nail Flexural/inverse Pustular
What is chronic plaque psoriasis?
Large salmon coloured plaques with thick scale
Who is guttate psoriasis seen in?
Mainly children and young adults
What is the appearance of guttate psoriasis?
Multiple pink papule wth fine scale
What is the appearance of nail psoriasis?
Pitting and oil spots on nails
What is the appearance of flexural/inverse psoriasis?
Less scaly
Skin pink-red sharply demarcated plaques
What is a complication of psoriasis?
Erythrodermic psoriasis
What is erythrodermic psoriasis?
Red man syndrome
>80% body covered
Erythematous with fine scale
What is the management of psoriasis?
- Topical emollient and vit D analogues
- phototherapy
- systemic medications
- biologics