Psoriasis Flashcards

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1
Q

What is psoriasis?

A

Chronic immune mediated disease

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2
Q

What is the pathophysiology of psoriasis?

A

Increased production of skin cells via autoimmune reaction

Cell cycle reduced from 28 to 5 days, –> build up of skin

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3
Q

What are the types of psoriasis?

A
1= familial, common, early onset
2= related to other autoimmune conditions and environment, older onset
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4
Q

What is the histology of psoriasis?

A

Hyperkeratosis
Dilated dermal capillaries
Neutrophils and T cell infiltration

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5
Q

What are the features of psoriasis?

A

Sharply demarcated, circumscribed erythematous plaques- scaly white superficial layer
Erythematous
Often symmetric

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6
Q

Where does psoriasis affect?

A

Extensor surfaces- elbows, knees
Scalp
Nail changes

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7
Q

What are the types of psoriasis? 7

A
Chronic plaque
Guttate
Palmo-plantar
Scalp
Nail
Flexural/inverse
Pustular
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8
Q

What is chronic plaque psoriasis?

A

Large salmon coloured plaques with thick scale

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9
Q

Who is guttate psoriasis seen in?

A

Mainly children and young adults

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10
Q

What is the appearance of guttate psoriasis?

A

Multiple pink papule wth fine scale

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11
Q

What is the appearance of nail psoriasis?

A

Pitting and oil spots on nails

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12
Q

What is the appearance of flexural/inverse psoriasis?

A

Less scaly

Skin pink-red sharply demarcated plaques

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13
Q

What is a complication of psoriasis?

A

Erythrodermic psoriasis

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14
Q

What is erythrodermic psoriasis?

A

Red man syndrome
>80% body covered
Erythematous with fine scale

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15
Q

What is the management of psoriasis?

A
  1. Topical emollient and vit D analogues
  2. phototherapy
  3. systemic medications
  4. biologics
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16
Q

What is the management of erythrodermic psoriasis?

A

Fluids and systemic treatment

Thick, greasy ointments/emollients