Pemphigus and pemphigoid

Question 1

What is pemphigus vulgaris?

Answer 1

Autoimmune blistering condition of epidermis

Question 2

What are antibodies against in pemphigus?

Answer 2

Desmosomes of epidermis

Question 3

What is the presentation of pemphigus>

Answer 3

Lesions and blisters on erythematous base
Easily rupture- bUSt
Painful but not itchy
Systemically unwell

Question 4

What are the common areas for pemphigus?

Answer 4

Mucous membranes

Typically starts in mouth and spreads to involve skin

Question 5

What is the management of pemphigus?

Answer 5

Systemic steroids
Immunosuppression
Supportive

Question 6

What is the prognosis of pemphigus?

Answer 6

Mortality ~15%

Persists for life

Question 7

What is pemphigoid?

Answer 7

Autoimmune condition affecting deeper into the skin and typically seen in older people

Question 8

What are antibodies against in pemphigoid?

Answer 8

Dermo-epidermal junction

Question 9

What is the presentation of pemphigoid?

Answer 9

Tense blisters that do not easily rupture
Intact epidermis forming roof of blister
Itchy and painful
Systemically well

Question 10

What are the common locations for pemphigoid?

Answer 10

Abdo and back
Arms and legs
NO mucous membranes

Question 11

What is the management of pemphigoid?

Answer 11

Steroids- topical or systemic

Immunosuppression

Question 12

What is the prognosis of pemphigoid?

Answer 12

Complete remission at 1 year common