Psoriasis

Question 1

What is Psoriasis

Answer 1

A complex, chronic inflammatory disease that involves hyperprolifereration of keratinocytes in the epidermis
-aka autoimmune disorder
-
Plaques of thickened, scaling skin, usually affecting the areas of the skin like elbow, knees and scalp

Question 2

Classification of Psoriasis

Answer 2

-chronic plaque (inflamed, red skin covered with silvery white scales)

-Guttate (causes small, pink-red spots on skin, appear in trunk, upper arms, thighs and scalp, triggered by stress, skin injury and certain drugs like beta blockers)

-Flexural (bright, red, smooth and shiny but don’t have scales)

-Erythrodermic (least common but very serious, affect whole body and cause widespread, fiery skin that appears burned, may also get fever, itching, burning, peeling, causes severe illness from protein and fluid loss infection, pneumonia, congestive heart failure)

-Pustular (mostly affect adults, caused pus-filled bumps surround by red skin affects hand and feet, sometimes most of the body, triggered by topical medicine-steroids, Pregnancy, infection, stress and exposure to certain chemicals

-Local forms

-psoriatic arthritis (have both psoriasis and arthritis, painful, stiff joints, swelling, most likely to have fungal infection)

Question 3

Causes of psoriasis

Answer 3

-unclear
-genetic
-immune system
-environmental

Question 4

Common triggers of psoriasis

Answer 4

-infections like streptococcal, viral
-skin trauma like Boehner phenomenon
-psychological stress
-drugs like lithium, beta blockers
-sunburn
-metabolic factors like calcium deficiency
-hormonal factors like pregnancy

Question 5

Signs and symptoms of psoriasis

Answer 5

-Red, raised, inflamed patches of skin
-soreness around patches
-thick pitted patches
-dry skin
-itching
-pain
-silver-white scales or plaques

Question 6

Pathogenesis of psoriasis

Answer 6

1. Genetic, environmental and immunological factor
2. Activated of T cells
3. Epidermis infiltration and keratinocytes profileration
4. Deregulated inflammatory process
5. Formation of psoriasis

Question 7

Treating psoriasis with general measures can

Answer 7

-reduce or eliminate potential trigger factors like stress, smoke, alcohol

Question 8

What do emollients used for in Topical therapies ?

Answer 8

-alleviate pruritus
-reduce scale
-enhance penetration of contaminant Topical therapy
-hydrate dry and cracked skin

Question 9

Pharmacological treatment for psoriasis

Answer 9

-Etanercept -Enbrel (binds tumor)
-Diprocel -Betamethasone dipropionate
-Remsima -Infliximab
-Stelar -Ustekinumab
-Methotrexate sodium -Rheumatrex
-coal tar shampoo -Polytar plus liquid

Question 10

Non-pharmacological treatment for psoriasis

Answer 10

-use moisture
-avoid triggers
-avoid alcohol
-stress management
-exercise
-healthy diet
-sunlight
-herbal shampoo
-salt water baths

Question 11

Complications of psoriasis

Answer 11

-folate deficiency
-cancers
-heart problems, obesity, diabetes
-bad body temperature regulation