Pseudomonas Aeruginosa Flashcards
Can P. aeruginosa ferment lactose? What is an example of the opposite?
No! E. Coli can.
Is pseudomonas oxidase positive or negative?
Oxidase positive
Is P. aeruginosa mucoid or non-mucoid?
It can be both, mucoid is worse.
What are the cellular structures that P. aeruginosa has?
Flagellum, pili!
What are some other virulence factors of P. aeruginosa.
LPS, siderophores, exotoxins, exoenximes, pyocianin
Who has special susceptibility to pseudomonas?
Patients with burns, patients with CF, patients with diabetes, and patients on chemo.
Clinical manifestations of P. aeruginosa
Bacteremia, endocarditis, folliculitis, otitis externa, respiratory infections.
Most common CFTR gene mutation?
DeltaF508
Common CF infections from least terrible to most?
S.Aureus, H influenzae, pseudomonas aeruginosa (nonmucoid), mucoid p. aeruginosa, burkholderia cepacia.
Why does CF lead to increased infection?
Abnormal CFTR causes abnormal epithelial cell function, which causes thickened secretions, allow bacterial colonization, increase in inflammatory cytokines, cell injury.
Antimicrobial agents for pseudomonas
Piperacillin/tazobactam, cetazidime, cefepime, imipenem-cilastatin, aztreonam, gentamicin,
Burkholderia cepacia causes…?
Catheter associated bacteremia, ventilator associated pneumonia
Stenotrophomonas maltophilia causes?
Catheter associated bacteremia, ventilator associated pneumonia.
Aminoglycosides
Streptomycin, gentamycin, tobramycin, amikacin
Where do most nosocomial infections occur?
Burn units, newborn ICU, M and S ICU, Oncology units.
