PSA basics

Question 1

Hyperkalemia causing drugs

Answer 1

SHANT - Spirnolactone, Heparins, ACE inhibitors, NSAIDs, Tacromilus

Question 2

Hypokalemia causing drugs

Answer 2

BTS, bendroflumethiaze, theophylline and salbutamol.

Question 3

Hypercalcemia causing drugs

Answer 3

Hydrochlorothiazide and other thiazide diuretics, vitamin D excess, lithium

Question 4

Hypocalcemia causing drugs

Answer 4

Bisphosphonates, corticosteroids, rifampin, calcitonin, chloroquine, cinacalcet, Denosumab, Foscarnet and plicamycin

Question 5

Nephrotoxic drugs

Answer 5

Diuretics
ACE inhibitors and ARBs
Metformin
NSAIDs

Question 6

1% =
50%

Answer 6

1% = 1 g in 100 ml ( =1000mg in 100ml = 10mg in 1 ml) 50% = 50 g in 100 ml (= 500 mg in 1 ml = 5 g in 10 ml)

Question 7

Drugs to avoid in myasthenia gravis?

Answer 7

• ## Avoid flouroquinolones, aminoglycosides and macrolides in myasthenia patients (FAM).

Question 8

Antibiotic to avoid in pregnancy

Answer 8

Avoid levofloxacin for epilepsy

Question 9

Tamoxifen risk

Answer 9

• Tamoxifen can increase risk of endometrial cancer (unopposed oestrogen)

Question 10

Finasteride risk

Answer 10

• ## Finasteride decreases levels of PSA and should not be used in obstructive uropathy.

Question 11

Withdrawing drugs pre-surgery?

Answer 11

SAWALL

Sex hormones (4 weeks), Aspirin (7 days), Warfarin (5 days), Apixaban (3 days), Lithium (24 hours), LMWH (12 hours)

• What is measured for levothyroxine and carmiazole? No routine tests for carbimazole but TSH is checked for levothyroxine
• Conti and Sequi Evorell
• Ethynylestradiol

Question 12

Drugs for acute and chronic mania

Answer 12

Olanzapine or benzodiazepines, whereas lithium is slower. Valproate is second line if lithium does not agree with the patient.

Question 13

Microgram drugs

Answer 13

Naloxone, Nitrates Levothyroxine, Tamulosin, digoxin, salbutamol, colchicine, folic acid

Never Lick That Doctor’s sexy crabby f**

Question 14

What antibiotics cause cholestasis?

Answer 14

Floucloxacillin

Question 15

What precaution should be taken when taking topirimate?

Answer 15

Stop taking progesterone contraceptive.

Question 16

What does a small rise in creatinine suggest when taking ACE inhibitors?

Answer 16

If <20% you do not have to stop the drug

Question 17

What is the most useful way to measure effectiveness of perindopril?

Answer 17

Exercise tolerance

Question 18

Name three drugs that might predipose a woman to vaginal candiasis?

Answer 18

Antibiotics x 2
Prednisolone

Question 19

Name a drug that interacts with simvastatin?

Answer 19

Gemfibrozil

Question 20

How are statins changed if CK is high?

Answer 20

Stop and restart and test if this has an effect