PROTOZOA (Hemoflagellates) Flashcards
Requires two hosts to survive
Hemoflagellates
Hemoflagellates
Definitive host:
Man
Hemoflagellates
Intermediate Host:
Arthropods/Vectors
Leishmania
Intermediate Host
Phlebotomus (sand flies)
Leishmania
Developmental stage
Amastigote and Promastigote
Leishmania
Infective stage to MAN
Promastigote
Trypanosoma brucei
Intermediate Host
Glossina (Tse-tse fly)
Trypanosoma brucei
Developmental stage
- Epimastigote,
-Trypomastigote,
-Metacystic trypomastigote
Trypanosoma brucei
Infective stage to MAN
Metacystic trypomastigote
Trypanosoma cruzi
Intermediate Host
- Reduviid bug
- Triatomine Kissing bug
- Assassin bug
Trypanosoma cruzi
Developmental stage
-Epimastigote
-Trypomastigote
-Metacystic trypomastigote
-Amastigote
Trypanosoma cruzi
Infective stage to MAN
Metacystic trypomastigote
lives intracellularly, found in monocyte, polymorphonuclear monocyte, endothelial cells Oval shape, 2-3 um diameter, no flagella and nucleus but with kinetoplast. Found on man
Leishmania (Mammalian type) / Amastigote
seen in intermediate host, found on transmitting fly, with flagellum at the anterior, no undulating membrane
Leptomonas / Promastigote
Seen in trypanosoma spp. transmitting flies, seen on salivary gland of the transmitting fly
Epimastigote / Crithidia
Seen trypanosoma spp., developed on MAN
Trypomastigote / Trypanosomal
Round to oval
Amastigote (Human)
Long and Slender
Promastigote (Vector)
Kinetoplast is present with dot like blepharoblast
Amastigote (Human)
One near center
Promastigote (Vector)
Parabasal body adjacent to blepharoblast, No flagellum
Amastigote (Human)
Free single flagella
Promastigote (Vector)
Usually found on cells
Amastigote (Human)
(deadliest among the three)
Leishmania donovani
Leishmania donovani
Spx of choice:
Aspiration
Associated diseases in Leishmania donovani
Visceral leishmaniasis
Kalazar fever
Dumdum fever
Black disease
Tropical splenomegaly
Leishmania tropica
Spx of choice:
Skin biopsy (superficial infestation)
Associated diseases in Leishmania tropica
Cutaneous leishmaniasis
Oriental sore
Aleppo
Baghdad boil
Delhi ulcer
Leishmania braziliensis
Spx of choice:
Tissue biopsy (infection caused by eating of the whole tissue -> deformity)
Associated diseases in Leishmania braziliensis
Mucocutaneous leishmaniasis
Espundia
Chiclero ulcer
American Leishmaniasis
Long and Slender (C, S, or U shape)
Trypomastigote (Human)
Long and wider than promastigote
Epimastigote (Vector)
Undulating membrane whole body length
Trypomastigote (Human)
Undulating membrane half of body length
Epimastigote (Vector)
Free flagellum
Trypomastigote (Human)
Epimastigote (Vector)
Trypanosome gambiensi
MOT:
Salivary skin inoculation (bite)
Disease Associated in Trypanosome gambiensi
West African Sleeping Sickness (circulates throughout the body, half awake, half sleep)
Winterbottom sign and Kerandel sign
Trypanosoma rhodesiense
MOT:
Salivary skin inoculation (bite)
Disease Associated in Trypanosoma rhodesiense
East African Sleeping Sickness
Trypanosoma cruzi
MOT:
Fecal transmission after skin inoculation
Disease Associated in Trypanosoma cruzi
South America trypanosomiasis
Chaga Chagoma and Romana sign
(deadliest among the three)
Trypanosoma cruzi