Proton Pump Inhibitors

Question 1

PPIs: Action?

Answer 1

• Decreases HCl acid secretion by increasing gastric mucus and bicarbonate production promoting ulcer healing

Question 2

PPIs: Naming?

Answer 2

• Names that end in “-azole”
• Examples - Esomeprazole (Nexium), Omeprazole (Prilosec), Lansoprazole (Prevacid), Rabeprazole (Aciphex)

Question 3

PPIs: Given to treat patients with…

Answer 3

• GERD
• Ulcers

Question 4

PPIs: Administration Instructions?

Answer 4

• Take 30 – 60 minutes before the meal preferably in the morning
• Instruct the patient not to chew or crush capsules
• Can open the capsule if not able to swallow and mix with apple sauce

Question 5

PPIs: SFX?

Answer 5

• Dizziness, diarrhea
• HA, N/V
• Abdominal pain
• Rash
• Upper respiratory tract infection

Question 6

How do PPIs affect Ampicilllin and Cyanocobalamin (man-made form of vitamin B12)?

Answer 6

• PPIs reduce the absorption of these drugs.

Question 7

How do PPIs affect the Diazepam, Phenytoin and Warfarin?

Answer 7

PPIs prolong elimination and increase effects of these drugs

Question 8

How do PPIs affect Digoxin?

Answer 8

PPIs increase digoxin absorption, which could lead to digoxin toxicity