Proteosome inh and Epigenteic Factor

Question 1

Carfilzomib

Answer 1

Proteosome inhibitor (20s)
For myeloma
Cause: Heart failure, fatigue, naus

Question 2

Farydak aka Panobinostat

Answer 2

For myeloma. Inhibits HDAC
Give with bortezomib (proteasome 26s inh) and dexamethasone.
Cuases diarrhea, fatigue, nausea

Question 3

Beleodaq

aka Belinostat

Answer 3

for replased or refractory PTCL. Inhibits histone Deactylase

Causes myelosuppression, naus, and fatigue

Question 4

Bortezomib

aka Velcade

Answer 4

proteasome inhibit (26s) for myeloma and NHL
Causes neuropathy, diarrhea, thrombocytopenia
interacts with 3A4 inducers, green tea, and 2C19 substrates. Take with food.

Question 5

Proteosome inhibitors end with

Answer 5

-omib

Question 6

HDAC inhibitors end with

Answer 6

-ostat