Lung cancer Flashcards
Small cell Lung cancer tx
Cisplatin + Etoposide
with cranial irradiation
Nonsmall cell lung cancer stage 1-3a
Surgery (only surg in stage 1)
Adjuvant Chemo (platinum based doublet)
Radiation for positive margins
Nonsmall cell lung cancer stage 3
Chemo/Radiation (platinum-doublet)
with Darvalumab
Platinum doublet agents for stage 3a
cisplatin+etoposide
cisplatin+vinblastine
carboplatin+pemetrexed
cisplatin+pemetrexed
When to use Durvalumab
after chemoraditation in stage 3.
Stage 4 treatment details
plat-doub for 4-6 cycles with ECOG 0-2.
Can add bevacizumab until disease progression
Platinum doublet agents for stage 4
all work the same!
Cisplatin and paclitaxel cisplatin plus gemcitabine cisplatin plus docetaxel cisplatin plus pemetrexed carboplatin plus paclitaxel
pemetrexed
only benefit in non-squamous cell
OK to start if didn’t have in initial therapy
possibilities for maintence therapy
Bevacizumab
erlotinib
pemetrexed
Afatinib
EGFR and HER2 inhibitor
skin and GI toxicity
ALK+ agents
Crizotinib (treats ROS1 too)
Alectinib
BRAF v600e agents
dabrafenib
trametinib
2nd line stage 4 treatment
docetaxel
pemetrexed
erlotinib
new drug for any EGFR mutation
osimertinib
