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Chemotherapy > Antimetabolites > Flashcards

Antimetabolites Flashcards

1
Q

Antimetabolites general MOA

A

structurally resemble normal intermediates in the biosynthesis of purines/pyrimidines, but inhibit the enzymes involved in transforming that intermediate

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2
Q

Folic Acid derivative agents

A

Methotrexate

Leucovorin

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3
Q

Pyrimidine Analogs

5-FU

A

5-Fluorouracil
certain tumors used more uric acid. Inhibits thymidylate synthase (the adder of methyl group). Causes dose-limiting myelosuppression and cardiotoxicity.

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4
Q

Methotrexate

A

blocks Dihydrofolate reductase. Affects S phase of cell cycle.

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5
Q

Leucovorin

A

repletes tetrahydrofolate. Po. Rescue. Doesn’t require reduction by DHFR to synthesize pyrimidines. But..enhances cytotoxic effects of 5-FU.

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Chemotherapy (20 decks)

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