Proteins Part 4 Flashcards
Precipitaion out of biochemical solution of denatured protein
Coagulation
A concentrated solution of protein albumin forms a jelly when heated because the albumin is denatured
Egg white
Protein denaturation
Cookin
Denatures protein maeks it easy for enzymes in our body to hydrolyze digest proteins
Kills microorganisms by denaturion of proteins
Protein denaturation
Cauterization
Heat is often used to seal small blood vessels
Heat induced denaturation
Sterilizing surgery equipment
Canning foods
Fever 102f ti 104f 40c
106f 41c extremely dangerous enzymes begin to deactivate
Denaturing agent
Heat MOA
Disrupts hydrogen bond by making molecules vibrate too violently coagulation like fried egg
Causes violent vibrations of molecules that disrupt hydrogen bonds
Microwave radiation
Similar to heat
Sunburning
Ultraviolet radiation
Globular proteins extend to longer length
Entangle (egg beating)
Violent whipping or shaking
Affects r group interaction
Detergent
Quickly denatures proteins in bacteria killing them
Organic solvents like ethanol acetone
Disrutps hydrogen bonds and salt bridges
Prolonged leads to actual hydrolysis of peptides
Strong acid and bases
Reduces disulfide linkages to produce -SH groups
Reducing agents
Conjugated proteins with carbohydrates linked to them
Blood group markers of the ABO system are
Many plasma membranes proteins are
Glycoproteins
Collagen and immunoglobulin are
Glycoproteins
Triple helix structure
Rich in 4-hydroxyproline 5% and hydroxylysine 1%
Collagen glycoprotein
Immunoglobulin
IgA
IgE
IgG
IgM
IgD
Soluble protein
Protective response
Antibodies against antigens
Immunoglobulins
First in response to microbial infection/antigen invasion
IgM
Largely responsible for long term immunity after infection or vaccination
IgG
A conjugated protein that contains lipids in addition to amino acids
Major func- help suspend lipids and transport them through the bloodstream
Lipoproteins
Four major classes of lipoproteins
Chylomicrons
Very low density lipoproteins VLDL
Low density lipoproteins LDL
High density lipoproteinsHDL
Transport dietary triacylglycerols from intestine to liver and to adipose tissue
Chylomicrons
Transport triacylglycerols synthesized in the liver to adipose tissue
VLDL
Transport cholesterol synthesized in the liver to cells throughout the body
LDL
Diseases involving proteins
Protein misfolding diseases
Protein deficiency diseases
Amino acid metabolism disorders
Protein deficiency diseases
Kwashiorkor
Marasmus
Edematous malnutrition
Kwashiorkor
Severe malnutrition
Marasmus