proteins

Question 1

backbone of polypeptide chain is

Answer 1

atoms that make up the covalent linkages from amino acid to next - everything but R groups

Question 2

bonds that exist in primary protein structure

Answer 2

cov between backbone atoms

Question 3

secondary structure of proteins

Answer 3

alpha helix and beta pleated sheet from nc interactions with nearby amino acids

Question 4

all bonds present in secondary protein structure

Answer 4

covalent between backbone, nc between backbone

Question 5

all bonds present in secondary protein structure

Answer 5

covalent between backbone, nc between backbone

Question 6

tertiary protein structure

Answer 6

3D shape of a polypeptide

Question 7

bonds present in tertiary protein structure

Answer 7

covalent between backbone, nc between backbone, covalent between R groups, nc between backbone and r groups, nc between r groups

Question 8

quaternary protein structure

Answer 8

structure formed by interactions between multiply polypeptides via nc interactions

Question 9

integral membrane proteins

Answer 9

transmembrane proteins span entire membrane

Question 10

peripheral membrane proteins

Answer 10

associated w lipid bilayer on either side, anchored by anchor proteins

Question 11

protein denaturation

Answer 11

loss of biological activity from protein unfolding, disruptions of non covalent interactions

change in pH, temp etc

proteins w/ strong interactions between side chains more difficult to denature

Question 12

protein renaturation

Answer 12

regaining activity

Question 13

factors that may affect interactions between r groups

Answer 13

size of chain, number of interactions (many ID-ID could be strong), location of the protein (interior/exterior, water or no)

Question 14

factors that may affect interactions between r groups

Answer 14

size of chain, number of interactions (many ID-ID could be strong), location of the protein (interior/exterior, water or no)

Question 15

conformational changes

Answer 15

shape of protein changes when a small molecule binds to the active site OR another site, allosteric site

Question 16

two types of allosteric changes

Answer 16

allosteric inhibition - substrate cannot bind because of conformational change caused by binding of inhibitor

allosteric activation - substrate CAN bind because of conformational change caused by binding of inhibitor