Protein Synthesis Inhibitors (Oxazolidnones)

Question 1

Oxazolidnones include :

Answer 1

1) Linezolid
2) Tedizolid

Question 2

MOA of linezolid :

Answer 2

Binds to the 23S ribosomal RNA of the 50S subunit , inhibiting the formation of the 70S initiation complex

Question 3

Antibacterial spectrum of Linezolid :

Answer 3

1) against MRSA ( methicillin resistant S.aureus )
2) against VRE ( Vancomycin-resistant enterococci )
3) Penicillin- resistant streptococci
4) Resistant Mycobacterium

Question 4

Linezolid is mainly ……………………but ………………… against ……………

Answer 4

Bacteriostatic / bactericidal / streptococci

Question 5

Clinical spectrum of Linezolid :

Answer 5

Treatment of drug- resistant gram positive organisms

Question 6

Linezolid drug is alternative of …………………….. for ……………..

Answer 6

Deptomycin / VRE

Question 7

Metabolism of Linezolid :

Answer 7

Oxidised in the liver into two inactive metabolites

Question 8

Elemination of Linezolid :

Answer 8

The two inactive metabolites are excreted in the urine

Question 9

Adverse effects of Linezolid :

Answer 9

1) GI upset ( Most common )
2) for patients taken the drug for more than 10 days , thrombocytopenia occurs
3) Serotonin Syndrome
4) Greater than 28 days of use , peripheral neuropathy occurs .