Cell Wall Inhibitors (Vancomycin ) Flashcards

1
Q

Vancomycin is ………

A

Tricyclic glycopeptide

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2
Q

MOA of vancomycin :

A

1) binds to peptidoglycan precursors
2) disrupting polymerisation and cross-linking required for maintenance of cell wall integrity.

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3
Q

Anti-bacterial spectrum of vancomycin:

A

Effective against gram-positive bacteria including MRSA and MSSE ( methicillin sensitive staphylococcus epidermidis )

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4
Q

Vancomycin pharmacodynamics :

A

1) bactericidal
2) time- and concentration- dependant antibiotic

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5
Q

MOR of vancomycin :

A

Alteration of binding affinity to peptidoglycan precursors

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6
Q

Administration of vancomycin :

A

Oral and IV

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7
Q

Oral vancomycin is used in :

A

Severe antibiotic associated pseudomembranous colitis

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8
Q

IV vancomycin is used in :

A

1) MRSA skin infections
2) infective endocarditis

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9
Q

Adverse effects of vancomycin :

A

1) Ototoxicity
2) Nephrotoxicity
3) Red man Syndrome

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