Cell Wall Inhibitors ( Other Beta-lactams )

Question 1

Other B-lactams include :

Answer 1

1) Carbapenem
2) monobactam

Question 2

Carbapenem derivatives :

Answer 2

1) Meropenem
2) Doripenem
3) Ertapenem
4) Imipenem / cilastatin

Question 3

Antibacterial Spectrum of Carbapenem :

Answer 3

1) broad-spectrum antibiotic
2) Resist beta lactamases so it is effective against beta-lactamase producing gram negative and gram positive microorganisms , anaerobes and pseudomonas aurigenosa

Question 4

Monobactam derivative :

Answer 4

Aztreonam

Question 5

Antibacterial spectrum of aztreonam :

Answer 5

• Lacks activity against gram-positive bacteria
• effective against gram-negative bacteria including P.aeruginosa
• susceptible to ESBLs

Question 6

Adverse effects of aztreonam:

Answer 6

1) Relatively non-toxic
2) little cross-reactivity with other beta lactams

Question 7

Combination of beta-lactamses and Carbapenem :

Answer 7

Meropenem and Vaborbactam

Question 8

Meropenem and Vaborbactam combination is effective against ………….. and indicated in ……… :

Answer 8

ESBL-producing bacteria / Management of complicated urinary tract infections