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Pharmacology > Protein Synthesis inhibitors, Others > Flashcards

Protein Synthesis inhibitors, Others Flashcards

1
Q

Tetracyclines
MOA
MOR

A

Competitive inhibition of A site

Drug efflux

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2
Q

Doxycycline

DOC- My Pink RBC

A 
My- Mycoplasma hominis
Pink- Prophylaxis of plague, pleurodesis, Pericardiodesis
R- Rickettsiae
B- Borrelia, Brucella
C- Chlamydia, Cholera
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3
Q

Demeclocycline use

A

SIADH

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4
Q

Sarecycline use

A

Acne

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5
Q

Omadacycline use

A

Pneumonia, Skin infection

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6
Q

Ervacycline use

A

Complicated abdominal infection

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7
Q

Tetracyclines safe in renal failure “TDM”

A

T- Tigecycline
D- Doxycycline
M- Minocycline

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8
Q

Vestibulotoxic antibiotics

A

Minocycline , Streptomycin

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9
Q

Aminoglycosides
spectrum
MOR

A 
Gram negative aerobes
Enzymatic inactivation (except amikacin, Netilmicin)
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10
Q

Aminoglycosides DOC

A

Plague

Tularemia (d/t Francisella tularensis)

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11
Q

Plazomicin use

A

Complicated UTI, Pyelonephritis

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12
Q

Tobramycin use

A

inhalational route for pseudomonas pneumonia in cystic fibrosis

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13
Q

Ototoxic aminglycosides

A

Max (KAN)- Kanamycin, Amikacin, Neomycin

Min - Netilmicin

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14
Q

Neuromuscular toxicity

A

Max - Neomycin

Min - Tobramycin

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15
Q

Macrolides

MOA

A

Inhibits translocase

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16
Q

Erythromycin DOC

A

Pertussis,
Diphtheria,
Prophylaxis of Rheumatic fever

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17
Q

Mitemcinal use

A

Gastroparesis (+ motilin R)

18
Q

Azithromycin DOC

A

Atypical pneumonia
Campylobacter
Chancroid
Chlamydia & Cholera in pregnancy

19
Q

Telithromycin
use
a/e

A

ketolide
use - CAP
a/e - hepatotoxic , worsen Myasthenia gravis

20
Q

Solithromycin

use

A

ketolide

use - CAP

21
Q 
Oxazolidinones
drugs
MOA
MOR
a/e
use
A 
Linezolid, Tedizolid, Sutezolid
Block translocation
Mutation of binding site
a/e - BM suppression, mitochondrial toxicity
use- MRSA, VRSA, DOC in VRE
22
Q 
Streptogramins
drugs
MOA
MOR
use
Elimination
A 
Quinipristine(30%), Dalfopristine(70%)
Block translocation 
MLS.B type of resistance
use- MRSA, VRSA, VRE
Hepatic elimination
23
Q 
Lincosamide
drugs
MOA
MOR
use
a/e
A

Clindamycin
blocks 50s translocation
MLS.B type of resistance
DOC - toxic shock syndrome (vancomycin), Prevotella
a/e - pseudomembranous enterocolitis, NM inhibition, SJS, thrombophlebitis.

24
Q

Fidaxomicin
MOA
use

A

Inhibits RNA polymerase

Pseudomembranous colitis in VRPE

25
Q 
Pleuromutilins
drugs
MOA
use 
a/e
A

Lefamulin, Retapamulin
blocks transpeptidation
use- CAP
a/e - QT prolongation, Hepatic elimination, C.I. in pregnancy

26
Q

Chloramphenicol
MOA
use
a/e

A

inhibits peptidyl transferase
use- resistant H. influenza, Meningococcal, Pneumococcus,
severe rickettsial disease.

a/e BM supression, Grey baby syndrome

27
Q

Mupirocin
MOA
use

A

inhibits tRNA synthase

(DOC) MRSA nasal carrier

28
Q

Fusidic acid

MOA

A

inhibits peptide elongation

29
Q

Rifaximin
MOA
use

A

inhibits RNA polymerase bactericidal

use- Gut sterilization in hepatic enceph, IBS diarrhoea, Pseudomembranous enterocolitis.

30
Q

Nalidixic acid
MOA
spectrum

A

DNA gyrase inhib

Gram- E.coli, Klebsiella, Serratia UTI

31
Q

Ciprofloxacin

DOC “A T Pay T M”

A 
Anthrax
Typhoid carrier
Pyelonephritis
Traveller's diarrhoea
contact of Meningococcal meningitis
32
Q

Pefloxacin

A

most lipid soluble

crosses BBB - meningitis

33
Q

Delafloxacin, Ozenoxacin

A

Bacterial skin infection

34
Q

QT prolongation in FQs

A

Max- Sparfloxacin, Moxifloxacin

Min- Ciprofloxacin

35
Q

FQs safe in renal failure

A

Pefloxacin, Moxifloxacin

36
Q

Cotrimoxazole DOC

A 
Pneumocystis
Cystitis
Prostatitis
Nocardiosis
Isosporiasis
Cyclosporiasis
Sarcocystosis
37
Q

Sulfisoxazole

use

A

Least crytalluria among sulfonamides

use- UTI, Cystitis

38
Q

Phenazopyridine

use

A

urinary anesthetic

39
Q

Nitrofuratoin a/e

A

Hemolysis in G6PD,
Peripheral Neuropathy,
Pulmonary fibrosis

40
Q

Pyronaridine

A

antimalarial

41
Q

Fidaxomicin

A

antibiotic as alternative to vancomycin in CLostridium difficile infection

Pharmacology (8 decks)

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